5MFQ
Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-344 at 1.90 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1 | polymer | 257 | 29108.5 | 2 | UniProt (P22756) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluK1,Glutamate receptor 5,GluR5,GluK1,Glutamate receptor 5,GluR5 |
| 2 | C, D (A) | 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 242.3 | 2 | Chemie (2J9) PubChem (67531324) | |||
| 3 | E, J (A, B) | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE | non-polymer | 213.2 | 2 | Chemie (KAI) PubChem (3816) PubChem (23616889) PubChem (10255) PubChem (73345) PubChem (45039619) PubChem (3083828) PubChem (5317452) PubChem (5318769) PubChem (6603893) PubChem (6453379) PubChem (6604705) PubChem (101994997) PubChem (10036135) PubChem (11095940) PubChem (135037246) | |||
| 4 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 5 | G, H, K (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) PubChem (753) | |||
| 6 | I, L (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 582 | Chemie (HOH) |
Sequence modifications
A, B: 430 - 544 (UniProt: P22756)
A, B: 667 - 805 (UniProt: P22756)
| PDB | External Database | Details |
|---|---|---|
| Gly 429 | - | cloning artifact |
| Gly 462 | Ala 462 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 545 | - | linker |
| Thr 546 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58216.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1414.9 | |
| All* | Total formula weight | 59631.8 |
