5MFQ
Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-344 at 1.90 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1 | polymer | 257 | 29108.5 | 2 | UniProt (P22756) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluK1,Glutamate receptor 5,GluR5,GluK1,Glutamate receptor 5,GluR5 |
| 2 | C, D (A) | 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 242.3 | 2 | Chemie (2J9) | |||
| 3 | E, J (A, B) | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE | non-polymer | 213.2 | 2 | Chemie (KAI) | |||
| 4 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | G, H, K (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | I, L (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 582 | Chemie (HOH) |
Sequence modifications
A, B: 430 - 544 (UniProt: P22756)
A, B: 667 - 805 (UniProt: P22756)
| PDB | External Database | Details |
|---|---|---|
| Gly 429 | - | cloning artifact |
| Gly 462 | Ala 462 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 545 | - | linker |
| Thr 546 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58216.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1414.9 | |
| All* | Total formula weight | 59631.8 |
