5MDI

Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	TAR DNA-binding protein 43	polymer	102	11445.4	2	UniProt (K7EJM5) Pfam (PF18694) UniProt (by SIFTS) (Q13148) In PDB	Homo sapiens (Human)
2	B	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
3		water	water		18.0	108	Chemie (HOH)

Sequence modifications

A, B: 2 - 80 (UniProt: K7EJM5)

PDB	External Database	Details
Met -21	-	initiating methionine
Gly -20	-	expression tag
Ser -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Leu -8	-	expression tag
Val -7	-	expression tag
Pro -6	-	expression tag
Arg -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	22890.8
Non-Polymers*	Number of molecules	1
	Total formula weight	59.0
All*	Total formula weight	22949.8

*Water molecules are not included.