5MC9

Crystal structure of the heterotrimeric integrin-binding region of laminin-111

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Laminin subunit alpha-1	polymer	633	69451.1	1	UniProt (P19137) Pfam (PF06009) Pfam (PF00054)	Mus musculus (Mouse)	Laminin A chain,Laminin-1 subunit alpha,Laminin-3 subunit alpha,S-laminin subunit alpha,S-LAM alpha
2	B (B)	Laminin subunit beta-1	polymer	56	6451.3	1	UniProt (P02469)	Mus musculus (Mouse)	Laminin B1 chain,Laminin-1 subunit beta,Laminin-10 subunit beta,Laminin-12 subunit beta,Laminin-2 subunit beta,Laminin-6 subunit beta,Laminin-8 subunit beta
3	C (C)	Laminin subunit gamma-1	polymer	64	7179.1	1	UniProt (P02468)	Mus musculus (Mouse)	Laminin B2 chain,Laminin-1 subunit gamma,Laminin-10 subunit gamma,Laminin-11 subunit gamma,Laminin-2 subunit gamma,Laminin-3 subunit gamma,Laminin-4 subunit gamma,Laminin-6 subunit gamma,Laminin-7 subunit gamma,Laminin-8 subunit gamma,Laminin-9 subunit gamma,S-laminin subunit gamma,S-LAM gamma
4	D, E (A)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
5	F, G, H (A, B, C)	water	water		18.0	294	Chemie (HOH)

Sequence modifications

A: 2079 - 2707 (UniProt: P19137)

PDB	External Database	Details
Ala 2075	-	expression tag
Pro 2076	-	expression tag
Leu 2077	-	expression tag
Ala 2078	-	expression tag

B: 1735 - 1786 (UniProt: P02469)

PDB	External Database	Details
Gly 1731	-	expression tag
Ala 1732	-	expression tag
Leu 1733	-	expression tag
Ala 1734	-	expression tag

C: 1548 - 1607 (UniProt: P02468)

PDB	External Database	Details
Ala 1544	-	expression tag
Pro 1545	-	expression tag
Leu 1546	-	expression tag
Ala 1547	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	83081.5
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	83161.7

*Water molecules are not included.