5MAI
Crystal structure of MELK in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Maternal embryonic leucine zipper kinase | polymer | 347 | 40220.5 | 1 | UniProt (Q14680) Pfam (PF00069) Pfam (PF21594) | Homo sapiens (Human) | hMELK,Protein kinase Eg3,pEg3 kinase,Protein kinase PK38,hPK38,Tyrosine-protein kinase MELK |
| 2 | B (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 3 | C (A) | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide | non-polymer | 464.6 | 1 | Chemie (5U5) | |||
| 4 | D (A) | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
A: 2 - 340 (UniProt: Q14680)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40220.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 542.7 | |
| All* | Total formula weight | 40763.2 |
