5MAH
Crystal structure of MELK in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Maternal embryonic leucine zipper kinase | polymer | 347 | 40220.5 | 1 | UniProt (Q14680) Pfam (PF00069) Pfam (PF21594) | Homo sapiens (Human) | hMELK,Protein kinase Eg3,pEg3 kinase,Protein kinase PK38,hPK38,Tyrosine-protein kinase MELK |
| 2 | B (A) | ~{N}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | non-polymer | 510.5 | 1 | Chemie (7KD) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E, F (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | G (A) | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A: 2 - 340 (UniProt: Q14680)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40220.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 684.0 | |
| All* | Total formula weight | 40904.6 |
