5M8R

Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with mimosine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	5,6-dihydroxyindole-2-carboxylic acid oxidase	polymer	446	50531.2	4	UniProt (P17643) Pfam (PF00264) In PDB	Homo sapiens (Human)	DHICA oxidase,Catalase B,Glycoprotein 75,Melanoma antigen gp75,Tyrosinase-related protein 1,TRP1
2	E, F, I, J	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	4	In PDB GlyTouCan (G21290RB)
3	G, K	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	H, L	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G48068RF)
5	M	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	1	In PDB GlyTouCan (G86851RC)
6	C, D, A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)
7	C, D, A, B	ZINC ION	non-polymer		65.4	9	Chemie (ZN)
8	C, D, A, B	MIMOSINE	non-polymer		198.2	4	Chemie (MMS)
9		water	water		18.0	39	Chemie (HOH)

Sequence modifications

A, B, C, D: 25 - 470 (UniProt: P17643)

PDB	External Database	Details
Phe 362	Tyr 362	engineered mutation
Ser 374	Arg 374	engineered mutation
Val 391	Thr 391	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	202124.6
Branched	Number of molecules	9
	Total formula weight	4995.7
Non-Polymers*	Number of molecules	24
	Total formula weight	3814.7
All*	Total formula weight	210935.0

*Water molecules are not included.