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5M6R

Human porphobilinogen deaminase in complex with reaction intermediate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BPorphobilinogen deaminasepolymer38942718.72UniProt (P08397)
Pfam (PF01379)
Pfam (PF03900)
In PDB
Homo sapiens (Human)PBG-D,Hydroxymethylbilane synthase,HMBS,Pre-uroporphyrinogen synthase
2A, B3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acidnon-polymer838.82Chemie (7J8)
3A, BPHOSPHATE IONnon-polymer95.03Chemie (PO4)
4A4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACIDnon-polymer238.31Chemie (EPE)
5waterwater18.023Chemie (HOH)
Sequence modifications
A, B: 1 - 361 (UniProt: P08397)
PDBExternal DatabaseDetails
Met -27-initiating methionine
Lys -26-expression tag
His -25-expression tag
His -24-expression tag
His -23-expression tag
His -22-expression tag
His -21-expression tag
His -20-expression tag
Pro -19-expression tag
Met -18-expression tag
Ser -17-expression tag
Asp -16-expression tag
Tyr -15-expression tag
Asp -14-expression tag
Ile -13-expression tag
Pro -12-expression tag
Thr -11-expression tag
Thr -10-expression tag
Glu -9-expression tag
Asn -8-expression tag
Leu -7-expression tag
Tyr -6-expression tag
Phe -5-expression tag
Gln -4-expression tag
Gly -3-expression tag
Ala -2-expression tag
Met -1-expression tag
Ala 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight85437.4
Non-Polymers*Number of molecules6
Total formula weight2200.8
All*Total formula weight87638.3
*Water molecules are not included.

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PDB entries from 2024-03-27

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