5M6R
Human porphobilinogen deaminase in complex with reaction intermediate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Porphobilinogen deaminase | polymer | 389 | 42718.7 | 2 | UniProt (P08397) Pfam (PF01379) Pfam (PF03900) In PDB | Homo sapiens (Human) | PBG-D,Hydroxymethylbilane synthase,HMBS,Pre-uroporphyrinogen synthase |
2 | A, B | 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid | non-polymer | 838.8 | 2 | Chemie (7J8) | |||
3 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
4 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
5 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 361 (UniProt: P08397)
PDB | External Database | Details |
---|---|---|
Met -27 | - | initiating methionine |
Lys -26 | - | expression tag |
His -25 | - | expression tag |
His -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
Pro -19 | - | expression tag |
Met -18 | - | expression tag |
Ser -17 | - | expression tag |
Asp -16 | - | expression tag |
Tyr -15 | - | expression tag |
Asp -14 | - | expression tag |
Ile -13 | - | expression tag |
Pro -12 | - | expression tag |
Thr -11 | - | expression tag |
Thr -10 | - | expression tag |
Glu -9 | - | expression tag |
Asn -8 | - | expression tag |
Leu -7 | - | expression tag |
Tyr -6 | - | expression tag |
Phe -5 | - | expression tag |
Gln -4 | - | expression tag |
Gly -3 | - | expression tag |
Ala -2 | - | expression tag |
Met -1 | - | expression tag |
Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 85437.4 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2200.8 | |
All* | Total formula weight | 87638.3 |