5M5A

Crystal structure of MELK in complex with an inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Maternal embryonic leucine zipper kinase	polymer	347	40220.5	1	UniProt (Q14680) Pfam (PF00069) Pfam (PF21594) In PDB	Homo sapiens (Human)	hMELK,Protein kinase Eg3,pEg3 kinase,Protein kinase PK38,hPK38,Tyrosine-protein kinase MELK
2	A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
3	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4	A	K-252A	non-polymer		467.5	1	Chemie (KSA)
5		water	water		18.0	106	Chemie (HOH)

Sequence modifications

A: 2 - 340 (UniProt: Q14680)

PDB	External Database	Details
Gly 0	-	expression tag
Pro 1	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40220.5
Non-Polymers*	Number of molecules	4
	Total formula weight	548.9
All*	Total formula weight	40769.4

*Water molecules are not included.