5M4U
ORTHORHOMBIC COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') WITH THE INHIBITOR 4'-CARBOXY-6,8-CHLORO- FLAVONOL (FLC21)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Casein kinase II subunit alpha' | polymer | 364 | 42821.8 | 1 | UniProt (P19784) Pfam (PF00069) | Homo sapiens (Human) | CK II alpha' |
| 2 | B (A) | 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid | non-polymer | 351.1 | 1 | Chemie (7FC) | |||
| 3 | C, D, E, F, G (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | H, I, J (A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | K (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | L (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | M (A) | water | water | 18.0 | 315 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P19784)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Gly 39 | Asp 39 | engineered mutation |
| Ser 336 | Cys 336 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42821.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1120.3 | |
| All* | Total formula weight | 43942.1 |
