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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5LZU

Structure of the mammalian ribosomal termination complex with accommodated eRF1

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		uL2polymer25728088.91UniProt (G1TT27)
Pfam (PF00181)
Pfam (PF03947)		Oryctolagus cuniculus (Rabbit)
2B
(B)		uL3polymer40346108.01UniProt (G1TL06)
Pfam (PF00297)		Oryctolagus cuniculus (Rabbit)
3C
(C)		uL4polymer42547727.61UniProt (G1SVW5)
Pfam (PF00573)
Pfam (PF14374)		Oryctolagus cuniculus (Rabbit)
4D
(D)		60S ribosomal protein L5polymer29734481.81UniProt (G1SYJ6)
Pfam (PF17144)
Pfam (PF14204)
UniProt (by SIFTS) (P19949)		Oryctolagus cuniculus (Rabbit)uL18
5E
(E)		60S ribosomal protein L6polymer29133028.31UniProt (G1SKF7)
Pfam (PF03868)
Pfam (PF01159)		Oryctolagus cuniculus (Rabbit)eL6
6F
(F)		uL30polymer24729201.81UniProt (G1SV32)
Pfam (PF08079)
Pfam (PF00327)		Oryctolagus cuniculus (Rabbit)
7G
(G)		eL8polymer31936221.51UniProt (G1STW0)
Pfam (PF01248)		Oryctolagus cuniculus (Rabbit)
8H
(H)		uL6polymer19221871.41UniProt (G1TX33)
Pfam (PF00347)
UniProt (by SIFTS) (G1SWI6)		Oryctolagus cuniculus (Rabbit)
9I
(I)		uL16polymer21424643.11UniProt (B7NZQ2)
Pfam (PF00252)		Oryctolagus cuniculus (Rabbit)Ribosomal protein L10 (Predicted)
10J
(J)		uL5polymer17820288.51UniProt (G1TUB8)
Pfam (PF00281)
Pfam (PF00673)		Oryctolagus cuniculus (Rabbit)
11K
(L)		eL13polymer21124331.71Oryctolagus cuniculus (Rabbit)
12L
(M)		eL14polymer21823870.51UniProt (G1SZ12)
Pfam (PF01929)		Oryctolagus cuniculus (Rabbit)
13M
(N)		Ribosomal protein L15polymer20424207.31UniProt (G1T0C1)
Pfam (PF00827)		Oryctolagus cuniculus (Rabbit)eL15
14N
(O)		uL13polymer20323533.31Oryctolagus cuniculus (Rabbit)
15O
(P)		uL22polymer18421444.21UniProt (G1TVT6)
Pfam (PF00237)
UniProt (by SIFTS) (G1SCJ6)		Oryctolagus cuniculus (Rabbit)
16P
(Q)		eL18polymer18821699.71Oryctolagus cuniculus (Rabbit)
17Q
(R)		eL19polymer19623535.31Oryctolagus cuniculus (Rabbit)
18R
(S)		eL20polymer17620827.61Oryctolagus cuniculus (Rabbit)
19S
(T)		eL21polymer16018610.01UniProt (G1SHQ2)
Pfam (PF01157)		Oryctolagus cuniculus (Rabbit)
20T
(U)		eL22polymer12814813.01Oryctolagus cuniculus (Rabbit)
21U
(V)		uL14polymer14014892.51UniProt (G1T6D1)
Pfam (PF00238)		Oryctolagus cuniculus (Rabbit)
22V
(W)		eL24polymer15717825.11UniProt (G1SE28)
Pfam (PF01246)		Oryctolagus cuniculus (Rabbit)
23W
(X)		uL23polymer15617768.21UniProt (G1SE76)
Pfam (PF03939)
Pfam (PF00276)		Oryctolagus cuniculus (Rabbit)
24X
(Y)		uL24polymer14517303.41UniProt (G1SQH0)
Pfam (PF16906)
Pfam (PF00467)		Oryctolagus cuniculus (Rabbit)
25Y
(Z)		60S ribosomal protein L27polymer13615835.81UniProt (G1TXF6)
Pfam (PF00467)
Pfam (PF01777)		Oryctolagus cuniculus (Rabbit)eL27
26Z
(a)		uL15polymer14816620.61UniProt (G1SNY0)
Pfam (PF00828)		Oryctolagus cuniculus (Rabbit)
27AA
(b)		eL29polymer24526708.71UniProt (G1SGR6)
Pfam (PF01779)		Oryctolagus cuniculus (Rabbit)
28BA
(c)		eL30polymer11512807.11UniProt (G1TDL2)
Pfam (PF01248)		Oryctolagus cuniculus (Rabbit)
29CA
(d)		eL31polymer12514494.91UniProt (G1SHG0)
Pfam (PF01198)		Oryctolagus cuniculus (Rabbit)
30DA
(e)		eL32polymer13515898.91UniProt (G1U437)
Pfam (PF01655)
UniProt (by SIFTS) (G1TUN8)		Oryctolagus cuniculus (Rabbit)
31EA
(f)		eL33polymer11012580.81UniProt (G1SF08)
Pfam (PF01247)		Oryctolagus cuniculus (Rabbit)
32FA
(g)		eL34polymer11713326.11UniProt (G1U945)
Pfam (PF01199)
UniProt (by SIFTS) (G1TXG5)		Oryctolagus cuniculus (Rabbit)
33GA
(h)		uL29polymer12314566.61UniProt (G1SIT5)
Pfam (PF00831)		Oryctolagus cuniculus (Rabbit)
34HA
(i)		60S ribosomal protein L36polymer10512263.81UniProt (G1TTQ5)
Pfam (PF01158)		Oryctolagus cuniculus (Rabbit)eL36
35IA
(j)		Ribosomal protein L37polymer9711111.01UniProt (U3KPD5)
Pfam (PF01907)		Oryctolagus cuniculus (Rabbit)eL37
36JA
(k)		eL38polymer708238.91UniProt (G1U001)
Pfam (PF01781)		Oryctolagus cuniculus (Rabbit)
37KA
(l)		eL39polymer516455.81UniProt (G1TTN1)
Pfam (PF00832)		Oryctolagus cuniculus (Rabbit)
38LA
(m)		eL40polymer10211699.81Oryctolagus cuniculus (Rabbit)
39MA
(n)		60s ribosomal protein l41polymer253473.51UniProt (A0A087WNH4)
Pfam (PF05162)		Oryctolagus cuniculus (Rabbit)eL41
40NA
(o)		eL42polymer10612477.01UniProt (G1U344)
Pfam (PF00935)
UniProt (by SIFTS) (G1T040)		Oryctolagus cuniculus (Rabbit)
41OA
(p)		eL43polymer9210299.41UniProt (G1SY53)
Pfam (PF01780)		Oryctolagus cuniculus (Rabbit)
42PA
(r)		eL28polymer13715783.61UniProt (G1U7L1)
Pfam (PF01778)		Oryctolagus cuniculus (Rabbit)
43QA
(s)		uL10polymer31834380.51Oryctolagus cuniculus (Rabbit)
44RA
(t)		uL11polymer16517847.61UniProt (G1SMR7)
Pfam (PF03946)
Pfam (PF00298)		Oryctolagus cuniculus (Rabbit)
45SA
(2)		P-site tRNApolymer7624436.61Oryctolagus cuniculus (Rabbit)
46TA
(3)		E-site tRNApolymer7524102.31Oryctolagus cuniculus (Rabbit)
47UA
(5)		28S ribosomal RNApolymer35431148115.41Oryctolagus cuniculus (Rabbit)
48VA
(7)		5S ribosomal RNApolymer12038691.91Oryctolagus cuniculus (Rabbit)
49WA
(8)		5.8S ribosomal RNApolymer15650143.61Oryctolagus cuniculus (Rabbit)
50XA
(9)		18S ribosomal RNApolymer1869602778.91Oryctolagus cuniculus (Rabbit)
51YA
(AA)		uS2polymer29532958.01Oryctolagus cuniculus (Rabbit)
52ZA
(BB)		40S ribosomal protein S3apolymer26430002.11UniProt (G1SS70)
Pfam (PF01015)		Oryctolagus cuniculus (Rabbit)
53AB
(CC)		uS5polymer29331327.41Oryctolagus cuniculus (Rabbit)
54BB
(DD)		uS3polymer24326715.31UniProt (G1TNM3)
Pfam (PF00189)
Pfam (PF07650)		Oryctolagus cuniculus (Rabbit)
55CB
(EE)		40S ribosomal protein S4polymer26329654.91UniProt (G1TK17)
Pfam (PF08071)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)		Oryctolagus cuniculus (Rabbit)
56DB
(FF)		uS7polymer20422913.51UniProt (G1TFM5)
Pfam (PF00177)		Oryctolagus cuniculus (Rabbit)
57EB
(GG)		40S ribosomal protein S6polymer24928751.91UniProt (G1TM55)
Pfam (PF01092)		Oryctolagus cuniculus (Rabbit)
58FB
(HH)		eS7polymer19422168.91UniProt (G1SVB0)
Pfam (PF01251)		Oryctolagus cuniculus (Rabbit)
59GB
(II)		40S ribosomal protein S8polymer20824263.41UniProt (G1TJW1)
Pfam (PF01201)		Oryctolagus cuniculus (Rabbit)
60HB
(JJ)		Ribosomal protein S9 (Predicted)polymer19422641.61UniProt (B7NZS8)
Pfam (PF00163)
Pfam (PF01479)		Oryctolagus cuniculus (Rabbit)
61IB
(KK)		eS10polymer16518933.81UniProt (G1TPV3)
Pfam (PF03501)		Oryctolagus cuniculus (Rabbit)
62JB
(LL)		uS17polymer15818468.81UniProt (G1TRM4)
Pfam (PF16205)
Pfam (PF00366)		Oryctolagus cuniculus (Rabbit)
63KB
(MM)		40S ribosomal protein S12polymer13214539.01UniProt (G1SFR8)
Pfam (PF01248)		Oryctolagus cuniculus (Rabbit)
64LB
(NN)		uS15polymer15117259.41UniProt (G1SP51)
Pfam (PF08069)
Pfam (PF00312)		Oryctolagus cuniculus (Rabbit)
65MB
(OO)		uS11polymer16818134.01UniProt (G1T1F0)
Pfam (PF00411)		Oryctolagus cuniculus (Rabbit)
66NB
(PP)		uS19polymer14517049.21UniProt (G1U0Q2)
Pfam (PF00203)		Oryctolagus cuniculus (Rabbit)
67OB
(QQ)		uS9polymer14616477.41UniProt (G1SGX4)
Pfam (PF00380)		Oryctolagus cuniculus (Rabbit)
68PB
(RR)		eS17polymer13515552.11UniProt (G1TU13)
Pfam (PF00833)		Oryctolagus cuniculus (Rabbit)
69QB
(SS)		uS13polymer15217759.81UniProt (G1TPG3)
Pfam (PF00416)		Oryctolagus cuniculus (Rabbit)
70RB
(TT)		eS19polymer14516106.61UniProt (G1TN62)
Pfam (PF01090)		Oryctolagus cuniculus (Rabbit)
71SB
(UU)		uS10polymer11913398.81UniProt (G1SIZ2)
Pfam (PF00338)		Oryctolagus cuniculus (Rabbit)
72TB
(VV)		eS21polymer839124.41Oryctolagus cuniculus (Rabbit)
73UB
(WW)		uS8polymer13014865.61UniProt (G1TG89)
Pfam (PF00410)		Oryctolagus cuniculus (Rabbit)
74VB
(XX)		uS12polymer14315844.71Oryctolagus cuniculus (Rabbit)
75WB
(YY)		eS24polymer13015107.91Oryctolagus cuniculus (Rabbit)
76XB
(ZZ)		eS25polymer12513776.21UniProt (G1TDB3)
Pfam (PF03297)		Oryctolagus cuniculus (Rabbit)
77YB
(aa)		eS26polymer11513047.51Oryctolagus cuniculus (Rabbit)
78ZB
(bb)		40S ribosomal protein S27polymer849480.21UniProt (G1TZ76)
Pfam (PF01667)		Oryctolagus cuniculus (Rabbit)
79AC
(cc)		eS28polymer697855.11UniProt (G1TIB4)
Pfam (PF01200)		Oryctolagus cuniculus (Rabbit)
80BC
(dd)		uS14polymer566690.81UniProt (G1U7M4)
Pfam (PF00253)		Oryctolagus cuniculus (Rabbit)
81CC
(ee)		eS30polymer13314498.91UniProt (G1T8A2)
Pfam (PF00240)
Pfam (PF04758)		Oryctolagus cuniculus (Rabbit)
82DC
(ff)		eS31polymer15618004.01UniProt (G1SK22)
Pfam (PF00240)
Pfam (PF01599)		Oryctolagus cuniculus (Rabbit)
83EC
(gg)		RACK1polymer31735115.71UniProt (G1SJB4)
Pfam (PF00400)		Oryctolagus cuniculus (Rabbit)
84FC
(hh)		mRNA (UGA stop codon)polymer154753.91Oryctolagus cuniculus (Rabbit)
85GC
(ii)		Eukaryotic peptide chain release factor subunit 1polymer45951639.51UniProt (P62495)
Pfam (PF03463)
Pfam (PF03464)
Pfam (PF03465)		Homo sapiens (Human)eRF1,Protein Cl1,TB3-1
86AD, AE, AF, AG, AH...
(5, 9, B, I, 7...)		MAGNESIUM IONnon-polymer24.3258Chemie (MG)
87JM, KM, LM, OC, QC...
(aa, dd, ff, g, j...)		ZINC IONnon-polymer65.48Chemie (ZN)
Sequence modifications
B: 2 - 403 (UniProt: G1TL06)
PDBExternal DatabaseDetails
Met 1-initiating methionine
C: 1 - 378 (UniProt: G1SVW5)
PDBExternal DatabaseDetails
Val 379-expression tag
Lys 380-expression tag
Lys 381-expression tag
Pro 382-expression tag
Arg 383-expression tag
Ala 384-expression tag
Val 385-expression tag
Gly 386-expression tag
Ile 387-expression tag
Lys 388-expression tag
Gln 389-expression tag
Lys 390-expression tag
Lys 391-expression tag
Lys 392-expression tag
Pro 393-expression tag
Val 394-expression tag
Val 395-expression tag
Gly 396-expression tag
Arg 397-expression tag
Lys 398-expression tag
Ala 399-expression tag
Ala 400-expression tag
Ala 401-expression tag
Ala 402-expression tag
Lys 403-expression tag
Lys 404-expression tag
Pro 405-expression tag
Ala 406-expression tag
Ala 407-expression tag
Asp 408-expression tag
Lys 409-expression tag
Lys 410-expression tag
Ala 411-expression tag
Ala 412-expression tag
Asp 413-expression tag
Lys 414-expression tag
Arg 415-expression tag
Ala 416-expression tag
Gly 417-expression tag
Pro 418-expression tag
Glu 419-expression tag
Asp 420-expression tag
Lys 421-expression tag
Lys 422-expression tag
Pro 423-expression tag
Ala 424-expression tag
Ala 425-expression tag
D: 2 - 297 (UniProt: G1SYJ6)
PDBExternal DatabaseDetails
Met 1-initiating methionine
F: 6 - 247 (UniProt: G1SV32)
PDBExternal DatabaseDetails
Met 1-initiating methionine
Glu 2-expression tag
Gly 3-expression tag
Ala 4-expression tag
Glu 5-expression tag
G: 78 - 319 (UniProt: G1STW0)
PDBExternal DatabaseDetails
Met 1-initiating methionine
Ser 2-expression tag
Ser 3-expression tag
Tyr 4-expression tag
Arg 5-expression tag
Leu 6-expression tag
Gly 7-expression tag
Tyr 8-expression tag
Cys 9-expression tag
Met 10-expression tag
Lys 11-expression tag
Glu 12-expression tag
Glu 13-expression tag
Arg 14-expression tag
His 15-expression tag
Asn 16-expression tag
Leu 17-expression tag
Val 18-expression tag
Leu 19-expression tag
Cys 20-expression tag
Leu 21-expression tag
Trp 22-expression tag
Ser 23-expression tag
Gln 24-expression tag
Ser 25-expression tag
Pro 26-expression tag
Gly 27-expression tag
Ile 28-expression tag
Leu 29-expression tag
Asn 30-expression tag
Ser 31-expression tag
Lys 32-expression tag
Cys 33-expression tag
Leu 34-expression tag
Trp 35-expression tag
Pro 36-expression tag
Phe 37-expression tag
Thr 38-expression tag
Asn 39-expression tag
Ile 40-expression tag
His 41-expression tag
Leu 42-expression tag
Leu 43-expression tag
Val 44-expression tag
Gly 45-expression tag
Ala 46-expression tag
Leu 47-expression tag
Pro 48-expression tag
Arg 49-expression tag
Glu 50-expression tag
Gly 51-expression tag
Ala 52-expression tag
Gly 53-expression tag
Gly 54-expression tag
Ala 55-expression tag
Trp 56-expression tag
Gly 57-expression tag
Gly 58-expression tag
Gly 59-expression tag
Arg 60-expression tag
Ser 61-expression tag
Glu 62-expression tag
Gln 63-expression tag
Leu 64-expression tag
Pro 65-expression tag
Thr 66-expression tag
Cys 67-expression tag
Ser 68-expression tag
Thr 69-expression tag
Thr 70-expression tag
His 71-expression tag
His 72-expression tag
Asp 73-expression tag
Phe 74-expression tag
Thr 75-expression tag
Trp 76-expression tag
Asp 77-expression tag
Gly 244Cys 167conflict
a: 1 - 148 (UniProt: G1SNY0)
PDBExternal DatabaseDetails
Met 1Gln 1conflict
b: 1 - 226 (UniProt: G1SGR6)
PDBExternal DatabaseDetails
Ala 227-expression tag
Pro 228-expression tag
Val 229-expression tag
Pro 230-expression tag
Ala 231-expression tag
Gln 232-expression tag
Ala 233-expression tag
Pro 234-expression tag
Pro 235-expression tag
Lys 236-expression tag
Gly 237-expression tag
Ala 238-expression tag
Gln 239-expression tag
Pro 240-expression tag
Pro 241-expression tag
Ala 242-expression tag
Lys 243-expression tag
Ala 244-expression tag
Pro 245-expression tag
g: 1 - 116 (UniProt: G1U945)
PDBExternal DatabaseDetails
Lys 117-expression tag
k: 1 - 70 (UniProt: G1U001)
PDBExternal DatabaseDetails
Lys 24Asn 24conflict
EE: 1 - 263 (UniProt: G1TK17)
PDBExternal DatabaseDetails
Gly 25Ser 25conflict
Arg 51Lys 51conflict
Thr 78Ala 78conflict
Val 156Met 156conflict
II: 1 - 208 (UniProt: G1TJW1)
PDBExternal DatabaseDetails
Arg 47Gly 47conflict
OO: -4 - 151 (UniProt: G1T1F0)
PDBExternal DatabaseDetails
Met -16-initiating methionine
Lys -15-expression tag
Ala -14-expression tag
Arg -13-expression tag
Ala -12-expression tag
Leu -11-expression tag
Ser -10-expression tag
Gly -9-expression tag
Ser -8-expression tag
Gly -7-expression tag
Val -6-expression tag
Arg -5-expression tag
TT: 1 - 145 (UniProt: G1TN62)
PDBExternal DatabaseDetails
Gly 119Trp 119conflict
ii: 1 - 437 (UniProt: P62495)
PDBExternal DatabaseDetails
Met -21-initiating methionine
Arg -20-expression tag
Gly -19-expression tag
Ser -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
Gly -11-expression tag
Met -10-expression tag
Ala -9-expression tag
Ser -8-expression tag
Glu -7-expression tag
Asn -6-expression tag
Leu -5-expression tag
Tyr -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains85
Total formula weight3466341.8
Non-Polymers*Number of molecules266
Total formula weight6794.0
All*Total formula weight3473135.8
*Water molecules are not included.

249697

PDB entries from 2026-02-25

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