5LYX

CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX; WITH AN INHIBITOR 5-((R)-1-[1,2,4]Triazolo[1,5-a]pyrimidin-7-yl-pyrrolidin-2-ylmethoxy)-isoquinoline

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Methionine aminopeptidase 2	polymer	378	42470.2	1	UniProt (P50579) Pfam (PF00557) In PDB	Homo sapiens (Human)	MetAP 2,Initiation factor 2-associated 67 kDa glycoprotein,p67eIF2,Peptidase M
2	A	5-[[(2~{R})-1-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-2-yl]methoxy]isoquinoline	non-polymer		346.4	1	Chemie (7BF)
3	A	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
4		water	water		18.0	128	Chemie (HOH)

Sequence modifications

A: 108 - 478 (UniProt: P50579)

PDB	External Database	Details
Met 107	-	initiating methionine
His 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag
His 482	-	expression tag
His 483	-	expression tag
His 484	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42470.2
Non-Polymers*	Number of molecules	3
	Total formula weight	456.3
All*	Total formula weight	42926.5

*Water molecules are not included.