5LUF
Cryo-EM of bovine respirasome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, L (c, l) | Cytochrome b-c1 complex subunit 1, mitochondrial | polymer | 446 | 49266.3 | 2 | UniProt (P31800) Pfam (PF00675) Pfam (PF05193) | Bos taurus (Bovine) | Complex III subunit 1,Core protein I,Ubiquinol-cytochrome-c reductase complex core protein 1 |
| 2 | B, M (m, n) | Cytochrome b-c1 complex subunit 2, mitochondrial | polymer | 439 | 46575.5 | 2 | UniProt (P23004) Pfam (PF00675) Pfam (PF05193) | Bos taurus (Bovine) | Complex III subunit 2,Core protein II,Ubiquinol-cytochrome-c reductase complex core protein 2 |
| 3 | C, N (b, o) | Cytochrome b | polymer | 379 | 42620.3 | 2 | UniProt (P00157) Pfam (PF00033) Pfam (PF00032) | Bos taurus (Bovine) | Complex III subunit 3,Complex III subunit III,Cytochrome b-c1 complex subunit 3,Ubiquinol-cytochrome-c reductase complex cytochrome b subunit |
| 4 | D, O (d, p) | Cytochrome c1, heme protein, mitochondrial | polymer | 241 | 27323.3 | 2 | UniProt (P00125) Pfam (PF02167) | Bos taurus (Bovine) | Complex III subunit 4,Complex III subunit IV,Cytochrome b-c1 complex subunit 4,Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit,Cytochrome c-1 |
| 5 | E, P (e, q) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 196 | 21640.6 | 2 | UniProt (P13272) Pfam (PF02921) Pfam (PF00355) | Bos taurus (Bovine) | Complex III subunit 5,Cytochrome b-c1 complex subunit 5,Rieske iron-sulfur protein,RISP,Ubiquinol-cytochrome c reductase iron-sulfur subunit |
| 6 | F, Q (f, r) | Cytochrome b-c1 complex subunit 7 | polymer | 110 | 13371.2 | 2 | UniProt (P00129) Pfam (PF02271) | Bos taurus (Bovine) | Complex III subunit 7,Complex III subunit VII,QP-C,Ubiquinol-cytochrome c reductase complex 14 kDa protein |
| 7 | G, R (g, s) | Cytochrome b-c1 complex subunit 8 | polymer | 81 | 9606.0 | 2 | UniProt (P13271) Pfam (PF02939) | Bos taurus (Bovine) | Complex III subunit 8,Complex III subunit VIII,Ubiquinol-cytochrome c reductase complex 9.5 kDa protein,Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C |
| 8 | H, S (h, t) | Cytochrome b-c1 complex subunit 6, mitochondrial | polymer | 78 | 9189.1 | 2 | UniProt (P00126) Pfam (PF02320) | Bos taurus (Bovine) | Complex III subunit 6,Complex III subunit VIII,Cytochrome c1 non-heme 11 kDa protein,Mitochondrial hinge protein,Ubiquinol-cytochrome c reductase complex 11 kDa protein |
| 9 | I, T (i, u) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 78 | 7964.3 | 2 | UniProt (P13272) Pfam (PF09165) | Bos taurus (Bovine) | Complex III subunit 5,Cytochrome b-c1 complex subunit 5,Rieske iron-sulfur protein,RISP,Ubiquinol-cytochrome c reductase iron-sulfur subunit |
| 10 | J, U (j, v) | Cytochrome b-c1 complex subunit 9 | polymer | 62 | 7209.3 | 2 | UniProt (P00130) Pfam (PF05365) | Bos taurus (Bovine) | Complex III subunit 9,Complex III subunit X,Cytochrome c1 non-heme 7 kDa protein,Ubiquinol-cytochrome c reductase complex 7.2 kDa protein |
| 11 | K, V (k, w) | Cytochrome b-c1 complex subunit 10 | polymer | 56 | 6370.4 | 2 | UniProt (P07552) Pfam (PF08997) | Bos taurus (Bovine) | Complex III subunit 10,Complex III subunit XI,Ubiquinol-cytochrome c reductase complex 6.4 kDa protein |
| 12 | W (x) | Cytochrome c oxidase subunit 1 | polymer | 514 | 57065.8 | 1 | UniProt (P00396) Pfam (PF00115) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide I |
| 13 | X (y) | Cytochrome c oxidase subunit 2 | polymer | 227 | 26040.4 | 1 | UniProt (P68530) Pfam (PF02790) Pfam (PF00116) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide II |
| 14 | Y (z) | Cytochrome c oxidase subunit 3 | polymer | 261 | 29943.6 | 1 | UniProt (P00415) Pfam (PF00510) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide III |
| 15 | Z (1) | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | polymer | 147 | 17179.6 | 1 | UniProt (P00423) Pfam (PF02936) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide IV,Cytochrome c oxidase subunit IV isoform 1,COX IV-1 |
| 16 | AA (2) | Cytochrome c oxidase subunit 5A, mitochondrial | polymer | 109 | 12453.1 | 1 | UniProt (P00426) Pfam (PF02284) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide Va |
| 17 | BA (3) | Cytochrome c oxidase subunit 5B, mitochondrial | polymer | 98 | 10684.0 | 1 | UniProt (P00428) Pfam (PF01215) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide VIa,Cytochrome c oxidase polypeptide Vb |
| 18 | CA (4) | Cytochrome c oxidase subunit 6A2, mitochondrial | polymer | 84 | 9452.7 | 1 | UniProt (P07471) Pfam (PF02046) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide VIa-heart,COXVIAH,Cytochrome c oxidase polypeptide VIb |
| 19 | DA (5) | Cytochrome c oxidase subunit 6B1 | polymer | 85 | 10039.2 | 1 | UniProt (P00429) Pfam (PF02297) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide VII,Cytochrome c oxidase subunit AED,Cytochrome c oxidase subunit VIb isoform 1,COX VIb-1 |
| 20 | EA (6) | Cytochrome c oxidase subunit 6C | polymer | 73 | 8495.0 | 1 | UniProt (P04038) Pfam (PF02937) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide VIc,Cytochrome c oxidase subunit STA |
| 21 | FA (7) | Cytochrome c oxidase subunit 7A1, mitochondrial | polymer | 59 | 6682.7 | 1 | UniProt (P07470) Pfam (PF02238) | Bos taurus (Bovine) | Cytochrome c oxidase subunit VIIIc,VIIIC,Cytochrome c oxidase subunit VIIa-heart,Cytochrome c oxidase subunit VIIa-H,Cytochrome c oxidase subunit VIIa-muscle,Cytochrome c oxidase subunit VIIa-M |
| 22 | GA (8) | Cytochrome c oxidase subunit 7B, mitochondrial | polymer | 56 | 6365.2 | 1 | UniProt (P13183) Pfam (PF05392) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide VIIb,IHQ |
| 23 | HA (9) | Cytochrome c oxidase subunit 7C, mitochondrial | polymer | 47 | 5449.4 | 1 | UniProt (P00430) Pfam (PF02935) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide VIIIA,Cytochrome c oxidase polypeptide VIIc |
| 24 | IA (0) | Cytochrome c oxidase subunit 8B, mitochondrial | polymer | 46 | 4967.8 | 1 | UniProt (P10175) Pfam (PF02285) | Bos taurus (Bovine) | Cytochrome c oxidase polypeptide VIII-heart,Cytochrome c oxidase subunit 8-1,Cytochrome c oxidase subunit 8H,IX,VIIIb |
| 25 | JA (A) | complex I | polymer | 111 | 9464.7 | 1 | Bos taurus | ||
| 26 | KA (B) | complex I | polymer | 143 | 12260.2 | 1 | Bos taurus | ||
| 27 | LA (C) | complex I | polymer | 154 | 13124.2 | 1 | Bos taurus | ||
| 28 | MA (D) | complex I | polymer | 384 | 32698.2 | 1 | Bos taurus | ||
| 29 | NA (E) | complex I | polymer | 159 | 13621.8 | 1 | Bos taurus | ||
| 30 | OA (F) | complex I | polymer | 411 | 35068.2 | 1 | Bos taurus | ||
| 31 | PA (G) | complex I | polymer | 538 | 46056.0 | 1 | Bos taurus | ||
| 32 | QA (H) | complex I | polymer | 313 | 26655.7 | 1 | Bos taurus | ||
| 33 | RA (I) | complex I | polymer | 162 | 13949.3 | 1 | Bos taurus | ||
| 34 | SA (J) | complex I | polymer | 171 | 14570.9 | 1 | Bos taurus | ||
| 35 | TA (K) | complex I | polymer | 84 | 7166.8 | 1 | Bos taurus | ||
| 36 | UA (L) | complex I | polymer | 601 | 51166.2 | 1 | Bos taurus | ||
| 37 | VA (M) | complex I | polymer | 453 | 38570.5 | 1 | Bos taurus | ||
| 38 | WA (N) | complex I | polymer | 345 | 29379.1 | 1 | Bos taurus | ||
| 39 | XA (O) | complex I | polymer | 220 | 18741.0 | 1 | Bos taurus | ||
| 40 | YA (P) | complex I | polymer | 303 | 25804.7 | 1 | Bos taurus | ||
| 41 | ZA (Q) | complex I | polymer | 85 | 7251.9 | 1 | Bos taurus | ||
| 42 | AB (R) | complex I | polymer | 47 | 4017.9 | 1 | Bos taurus | ||
| 43 | BB (S) | complex I | polymer | 80 | 6826.4 | 1 | Bos taurus | ||
| 44 | CB (T) | complex I | polymer | 75 | 6400.9 | 1 | Bos taurus | ||
| 45 | DB (V) | complex I | polymer | 71 | 6060.5 | 1 | Bos taurus | ||
| 46 | EB (W) | complex I | polymer | 72 | 6145.6 | 1 | Bos taurus | ||
| 47 | FB (X) | complex I | polymer | 330 | 28102.5 | 1 | Bos taurus | ||
| 48 | GB (Y) | complex I | polymer | 106 | 9039.1 | 1 | Bos taurus | ||
| 49 | HB (a) | complex I | polymer | 142 | 12102.9 | 1 | Bos taurus | ||
| 50 | IB (U) | complex I | polymer | 828 | 70484.5 | 1 | Bos taurus | ||
| 51 | JB (Z) | complex I | polymer | 625 | 53208.7 | 1 | Bos taurus | ||
| 52 | KB, LB, NB, OB (b, o) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 53 | MB, PB (d, p) | HEME C | non-polymer | 618.5 | 2 | Chemie (HEC) | |||
| 54 | DC, QB, ZB (G, q, E) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 3 | Chemie (FES) | |||
| 55 | RB, VB, WB (x, y) | COPPER (II) ION | non-polymer | 63.5 | 3 | Chemie (CU) | |||
| 56 | SB (x) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 57 | TB, UB (x) | HEME-A | non-polymer | 852.8 | 2 | Chemie (HEA) | |||
| 58 | XB (3) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 59 | AC, BC, CC, EC, FC... (F, G, I, B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) |
Sequence modifications
f, r: 1 - 110 (UniProt: P00129)
k, w: 1 - 56 (UniProt: P07552)
z: 1 - 261 (UniProt: P00415)
| PDB | External Database | Details |
|---|---|---|
| Asp 56 | Asn 57 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gln 22 | Ser 22 | conflict |
| Ser 34 | Trp 34 | conflict |
| Ser 38 | Trp 38 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 238 | Ala 238 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 62 |
| Total formula weight | 1285029.5 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 8326.3 | |
| All* | Total formula weight | 1293355.7 |
