5LSK

CRYSTAL STRUCTURE OF THE HUMAN KINETOCHORE MIS12-CENP-C COMPLEX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Protein MIS12 homolog	polymer	205	24170.9	1	UniProt (Q9H081) Pfam (PF05859) In PDB	Homo sapiens (Human)
2	B	Polyamine-modulated factor 1	polymer	176	20522.4	1	UniProt (Q6P1K2) Pfam (PF03980) In PDB	Homo sapiens (Human)	PMF-1
3	D	Kinetochore-associated protein DSN1 homolog	polymer	296	33848.2	1	UniProt (Q9H410) Pfam (PF08202) In PDB	Homo sapiens (Human)
4	N	Kinetochore-associated protein NSL1 homolog	polymer	206	23307.6	1	UniProt (Q96IY1) Pfam (PF08641) In PDB	Homo sapiens (Human)
5	P	Centromere protein C	polymer	76	8501.5	1	UniProt (Q03188) In PDB	Homo sapiens (Human)	CENP-C,Centromere autoantigen C,Centromere protein C 1,CENP-C 1,Interphase centromere complex protein 7
6		water	water		18.0	6	Chemie (HOH)

Sequence modifications

B: 31 - 205 (UniProt: Q6P1K2)

PDB	External Database	Details
Met 30	-	initiating methionine

D: 68 - 356 (UniProt: Q9H410)

PDB	External Database	Details
Met 67	-	initiating methionine
His 357	-	expression tag
His 358	-	expression tag
His 359	-	expression tag
His 360	-	expression tag
His 361	-	expression tag
His 362	-	expression tag

P: 1 - 71 (UniProt: Q03188)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	110350.6
All*	Total formula weight	110350.6

*Water molecules are not included.