5LS6
Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D, G, J | Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2 | polymer | 695 | 79494.4 | 4 | UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) In PDB | Homo sapiens (Human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6,ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6,ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
2 | B, E, H, K | Polycomb protein EED | polymer | 367 | 42314.1 | 4 | UniProt (O75530) Pfam (PF00400) In PDB | Homo sapiens (Human) | hEED,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
3 | C, F, I, L | Polycomb protein SUZ12 | polymer | 129 | 15249.5 | 4 | UniProt (Q15022) Pfam (PF09733) In PDB | Homo sapiens (Human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
4 | Q, R, S, T | Jarid2 K116me3 | polymer | 11 | 1377.6 | 4 | UniProt (by SIFTS) (Q92833) In PDB | Homo sapiens | |
5 | D, G, A, J | ZINC ION | non-polymer | 65.4 | 32 | Chemie (ZN) | |||
6 | D, G, A, J | 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide | non-polymer | 514.6 | 4 | Chemie (74D) |
Sequence modifications
A, D, G, J: 1 - 182 (UniProt: Q15910)
A, D, G, J: 211 - 418 (UniProt: Q15910)
A, D, G, J: 421 - 746 (UniProt: Q15910)
B, E, H, K: 77 - 441 (UniProt: O75530)
C, F, I, L: 558 - 685 (UniProt: Q15022)
PDB | External Database | Details |
---|---|---|
Glu -9 | - | expression tag |
Thr -8 | - | expression tag |
Ser -7 | - | expression tag |
Leu -6 | - | expression tag |
Ala -5 | - | expression tag |
Glu -4 | - | expression tag |
Glu -3 | - | expression tag |
Lys -2 | - | expression tag |
Leu -1 | - | expression tag |
Thr 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gln 249 | Glu 249 | conflict |
PDB | External Database | Details |
---|---|---|
Pro 419 | - | linker |
Gly 420 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 75 | - | expression tag |
Ser 76 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 557 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 16 |
Total formula weight | 553742.7 | |
Non-Polymers* | Number of molecules | 36 |
Total formula weight | 4151.5 | |
All* | Total formula weight | 557894.2 |