5LS6

Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2	polymer	695	79494.4	4	UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856)	Homo sapiens (Human)	ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6,ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6,ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
2	B, E, H, K (B, E, H, K)	Polycomb protein EED	polymer	367	42314.1	4	UniProt (O75530) Pfam (PF00400)	Homo sapiens (Human)	hEED,WD protein associating with integrin cytoplasmic tails 1,WAIT-1
3	C, F, I, L (C, F, I, L)	Polycomb protein SUZ12	polymer	129	15249.5	4	UniProt (Q15022) Pfam (PF09733)	Homo sapiens (Human)	Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
4	M, N, O, P (Q, R, S, T)	Jarid2 K116me3	polymer	11	1377.6	4	UniProt (by SIFTS) (Q92833)	Homo sapiens
5	AA, BA, CA, DA, EA... (D, G, A, J)	ZINC ION	non-polymer		65.4	32	Chemie (ZN)
6	HA, QA, Y, ZA (D, G, A, J)	1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide	non-polymer		514.6	4	Chemie (74D)

Sequence modifications

A, D, G, J: 1 - 182 (UniProt: Q15910)

PDB	External Database	Details
Glu -9	-	expression tag
Thr -8	-	expression tag
Ser -7	-	expression tag
Leu -6	-	expression tag
Ala -5	-	expression tag
Glu -4	-	expression tag
Glu -3	-	expression tag
Lys -2	-	expression tag
Leu -1	-	expression tag
Thr 0	-	expression tag

A, D, G, J: 211 - 418 (UniProt: Q15910)

PDB	External Database	Details
Gln 249	Glu 249	conflict

A, D, G, J: 421 - 746 (UniProt: Q15910)

PDB	External Database	Details
Pro 419	-	linker
Gly 420	-	linker

B, E, H, K: 77 - 441 (UniProt: O75530)

PDB	External Database	Details
Gly 75	-	expression tag
Ser 76	-	expression tag

C, F, I, L: 558 - 685 (UniProt: Q15022)

PDB	External Database	Details
Gly 557	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	553742.7
Non-Polymers*	Number of molecules	36
	Total formula weight	4151.5
All*	Total formula weight	557894.2

*Water molecules are not included.