5LRQ
BRD4 in complex with ERK5 inhibitor XMD8-92
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Bromodomain-containing protein 4 | polymer | 143 | 16915.3 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
2 | A | 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one | non-polymer | 474.6 | 1 | Chemie (4WG) | |||
3 | water | water | 18.0 | 114 | Chemie (HOH) |
Sequence modifications
A: 42 - 163 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Met 21 | - | initiating methionine |
His 22 | - | expression tag |
His 23 | - | expression tag |
His 24 | - | expression tag |
His 25 | - | expression tag |
His 26 | - | expression tag |
His 27 | - | expression tag |
Ser 28 | - | expression tag |
Ser 29 | - | expression tag |
Gly 30 | - | expression tag |
Val 31 | - | expression tag |
Asp 32 | - | expression tag |
Leu 33 | - | expression tag |
Gly 34 | - | expression tag |
Thr 35 | - | expression tag |
Glu 36 | - | expression tag |
Asn 37 | - | expression tag |
Leu 38 | - | expression tag |
Tyr 39 | - | expression tag |
Phe 40 | - | expression tag |
Gln 41 | - | expression tag |
Met 43 | Thr 43 | conflict |
Ala 58 | Arg 58 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 16915.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 474.6 | |
All* | Total formula weight | 17389.9 |