5LQW
yeast activated spliceosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Pre-mRNA-splicing factor 8 | polymer | 2413 | 279850.4 | 1 | UniProt (P33334) Pfam (PF08082) Pfam (PF08083) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) Pfam (PF12134) Pfam (PF08084) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 2 | B | Pre-mRNA-splicing factor SNU114 | polymer | 1008 | 114174.0 | 1 | UniProt (P36048) Pfam (PF03764) Pfam (PF00679) Pfam (PF16004) Pfam (PF00009) In PDB | Saccharomyces cerevisiae (Baker's yeast) | 114 kDa U5 small nuclear ribonucleoprotein component,Growth inhibitory protein 10 |
| 3 | C | Pre-mRNA-splicing helicase BRR2 | polymer | 2163 | 246470.3 | 1 | UniProt (P32639) Pfam (PF21188) Pfam (PF18149) Pfam (PF00270) Pfam (PF00271) Pfam (PF02889) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Protein Snu246 |
| 4 | D | Pre-mRNA-splicing factor SLT11 | polymer | 364 | 40988.6 | 1 | UniProt (P38241) Pfam (PF21369) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Extracellular mutant protein 2,Synthetic lethality with U2 protein 11 |
| 5 | E | Pre-mRNA-splicing factor BUD31 | polymer | 157 | 18484.5 | 1 | UniProt (P25337) Pfam (PF01125) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Bud site selection protein 31,Complexed with CEF1 protein 14 |
| 6 | F | Pre-mRNA-splicing factor CWC2 | polymer | 339 | 38486.6 | 1 | UniProt (Q12046) Pfam (PF16131) Pfam (PF00076) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Complexed with CEF1 protein 2,PRP19-associated complex protein 40,Synthetic lethal with CLF1 protein 3 |
| 7 | H | Pre-mRNA-splicing factor CWC22 | polymer | 577 | 67386.1 | 1 | UniProt (P53333) Pfam (PF02847) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Complexed with CEF1 protein 22 |
| 8 | J | U2 snRNP component IST3 | polymer | 148 | 17121.1 | 1 | UniProt (P40565) Pfam (PF00076) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Increased sodium tolerance protein 3,U2 snRNP protein SNU17 |
| 9 | K | Pre-mRNA-splicing factor PRP46 | polymer | 451 | 50771.3 | 1 | UniProt (Q12417) Pfam (PF00400) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Complexed with CEF1 protein 1,PRP nineteen-associated complex protein 50,PRP19-associated complex protein 50,Pre-mRNA-processing protein 46 |
| 10 | L | Pre-mRNA-splicing factor CWC26 | polymer | 266 | 30529.1 | 1 | UniProt (P46947) Pfam (PF09736) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Bud site selection protein 13,Complexed with CEF1 protein 26,Synthetic lethal with CLF1 protein 7 |
| 11 | M | Pre-mRNA-processing protein 45 | polymer | 379 | 42548.7 | 1 | UniProt (P28004) Pfam (PF02731) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 12 | N | Pre-mRNA leakage protein 1 | polymer | 204 | 23685.7 | 1 | UniProt (Q07930) Pfam (PF00498) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 13 | O | Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 | polymer | 876 | 99947.5 | 1 | UniProt (P20095) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Pre-mRNA-processing protein 2 |
| 14 | P | Pre-mRNA-splicing factor SYF1 | polymer | 859 | 100344.0 | 1 | UniProt (Q04048) Pfam (PF05843) In PDB | Saccharomyces cerevisiae (Baker's yeast) | PRP19-associated complex protein 90,Synthetic lethal with CDC40 protein 1 |
| 15 | Q | U2 snRNP component HSH155 | polymer | 971 | 110166.7 | 1 | UniProt (P49955) Pfam (PF22646) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 16 | R | Pre-mRNA-splicing factor CLF1 | polymer | 687 | 82555.9 | 1 | UniProt (Q12309) Pfam (PF05843) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Crooked neck-like factor 1,PRP19-associated complex protein 77,Synthetic lethal with CDC40 protein 3 |
| 17 | W | Pre-mRNA-splicing factor CEF1 | polymer | 590 | 67837.8 | 1 | UniProt (Q03654) Pfam (PF00249) Pfam (PF11831) In PDB | Saccharomyces cerevisiae (Baker's yeast) | PRP nineteen-associated complex protein 85,PRP19-associated complex protein 85 |
| 18 | X | Pre-mRNA-splicing factor RSE1 | polymer | 1361 | 153956.8 | 1 | UniProt (Q04693) Pfam (PF10433) Pfam (PF03178) In PDB | Saccharomyces cerevisiae (Baker's yeast) | RNA splicing and ER to Golgi transport factor 1,Spliceosome-associated protein 130 |
| 19 | Y | Pre-mRNA-splicing factor RDS3 | polymer | 107 | 12283.6 | 1 | UniProt (Q06835) Pfam (PF03660) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Regulator of drug sensitivity 3 |
| 20 | Z | RDS3 complex subunit 10 | polymer | 85 | 10045.4 | 1 | UniProt (P0C074) Pfam (PF07189) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Splicing factor 3b subunit |
| 21 | b | Small nuclear ribonucleoprotein-associated protein B | polymer | 196 | 22427.0 | 1 | UniProt (P40018) Pfam (PF01423) In PDB | Saccharomyces cerevisiae (Baker's yeast) | snRNP-B,Sm protein B,SmB |
| 22 | d | Small nuclear ribonucleoprotein Sm D3 | polymer | 101 | 11240.1 | 1 | UniProt (P43321) Pfam (PF01423) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Sm-D3,snRNP core protein D3 |
| 23 | e | Small nuclear ribonucleoprotein E | polymer | 94 | 10385.1 | 1 | UniProt (Q12330) Pfam (PF01423) In PDB | Saccharomyces cerevisiae (Baker's yeast) | snRNP-E,Sm protein E,SmE |
| 24 | f | Small nuclear ribonucleoprotein F | polymer | 86 | 9669.9 | 1 | UniProt (P54999) Pfam (PF01423) In PDB | Saccharomyces cerevisiae (Baker's yeast) | snRNP-F,Sm protein F,SmF |
| 25 | g | Small nuclear ribonucleoprotein G | polymer | 77 | 8490.8 | 1 | UniProt (P40204) Pfam (PF01423) In PDB | Saccharomyces cerevisiae (Baker's yeast) | snRNP-G,Sm protein G,SmG |
| 26 | h | Small nuclear ribonucleoprotein Sm D1 | polymer | 146 | 16296.8 | 1 | UniProt (Q02260) Pfam (PF01423) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Sm-D1,snRNP core protein D1 |
| 27 | j | Small nuclear ribonucleoprotein Sm D2 | polymer | 110 | 12876.1 | 1 | UniProt (Q06217) Pfam (PF01423) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Sm-D2,snRNP core protein D2 |
| 28 | 2 | U2 snRNA | polymer | 1175 | 376267.4 | 1 | Saccharomyces cerevisiae (Baker's yeast) | ||
| 29 | 5 | U5 snRNA | polymer | 179 | 57444.9 | 1 | Saccharomyces cerevisiae (Baker's yeast) | ||
| 30 | 6 | U6 snRNA | polymer | 112 | 35883.2 | 1 | Saccharomyces cerevisiae (Baker's yeast) | ||
| 31 | 9 | actin pre-mRNA | polymer | 572 | 182574.9 | 1 | Saccharomyces cerevisiae |
Sequence modifications
A: 1 - 2413 (UniProt: P33334)
| PDB | External Database | Details |
|---|---|---|
| Asn 153 | Met 153 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 31 |
| Total formula weight | 2351190.1 | |
| All* | Total formula weight | 2351190.1 |
