5LKZ

Crystal structure of the p300 acetyltransferase catalytic core with crotonyl-coenzyme A.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histone acetyltransferase p300,Histone acetyltransferase p300	polymer	578	67102.7	1	UniProt (Q09472) Pfam (PF00439) Pfam (PF06001) Pfam (PF08214) In PDB	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,p300 HAT,E1A-associated protein p300
2	A	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
3	A	CROTONYL COENZYME A	non-polymer		835.6	1	Chemie (COO)
4	A	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
5		water	water		18.0	158	Chemie (HOH)

Sequence modifications

A: 1043 - 1519 (UniProt: Q09472)

PDB	External Database	Details
Gly 1033	-	expression tag
Ala 1034	-	expression tag
Met 1035	-	expression tag
Ala 1036	-	expression tag
Gly 1037	-	expression tag
Lys 1038	-	expression tag
Ala 1039	-	expression tag
Val 1040	-	expression tag
Pro 1041	-	expression tag
Met 1042	-	expression tag
Phe 1467	Tyr 1467	engineered mutation

A: 1581 - 1666 (UniProt: Q09472)

PDB	External Database	Details
Ser 1520	-	linker
Gly 1521	-	linker
Gly 1522	-	linker
Ser 1523	-	linker
Gly 1524	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	67102.7
Non-Polymers*	Number of molecules	8
	Total formula weight	1373.5
All*	Total formula weight	68476.2

*Water molecules are not included.