5LKU

Crystal structure of the p300 acetyltransferase catalytic core with coenzyme A.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone acetyltransferase p300,Histone acetyltransferase p300	polymer	578	67102.7	1	UniProt (Q09472) Pfam (PF00439) Pfam (PF06001) Pfam (PF08214)	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,p300 HAT,E1A-associated protein p300
2	B, C, D, E (A)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
3	F (A)	COENZYME A	non-polymer		767.5	1	Chemie (COA)
4	G (A)	water	water		18.0	16	Chemie (HOH)

Sequence modifications

A: 1043 - 1519 (UniProt: Q09472)

PDB	External Database	Details
Gly 1033	-	expression tag
Ala 1034	-	expression tag
Met 1035	-	expression tag
Ala 1036	-	expression tag
Gly 1037	-	expression tag
Lys 1038	-	expression tag
Ala 1039	-	expression tag
Val 1040	-	expression tag
Pro 1041	-	expression tag
Met 1042	-	expression tag
Phe 1467	Tyr 1467	engineered mutation

A: 1581 - 1666 (UniProt: Q09472)

PDB	External Database	Details
Ser 1520	-	linker
Gly 1521	-	linker
Gly 1522	-	linker
Ser 1523	-	linker
Gly 1580	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	67102.7
Non-Polymers*	Number of molecules	5
	Total formula weight	1029.2
All*	Total formula weight	68131.9

*Water molecules are not included.