5LKT
Crystal structure of the p300 acetyltransferase catalytic core with butyryl-coenzyme A.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone acetyltransferase p300,Histone acetyltransferase p300 | polymer | 578 | 67102.7 | 1 | UniProt (Q09472) Pfam (PF00439) Pfam (PF06001) Pfam (PF08214) | Homo sapiens (Human) | p300 HAT,E1A-associated protein p300,p300 HAT,E1A-associated protein p300 |
| 2 | B, C, D, E (A) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F (A) | Butyryl Coenzyme A | non-polymer | 837.6 | 1 | Chemie (BCO) | |||
| 4 | G, H, I (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | J (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | K (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | L (A) | water | water | 18.0 | 384 | Chemie (HOH) |
Sequence modifications
A: 1043 - 1519 (UniProt: Q09472)
A: 1581 - 1666 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Gly 1033 | - | expression tag |
| Ala 1034 | - | expression tag |
| Met 1035 | - | expression tag |
| Ala 1036 | - | expression tag |
| Gly 1037 | - | expression tag |
| Lys 1038 | - | expression tag |
| Ala 1039 | - | expression tag |
| Val 1040 | - | expression tag |
| Pro 1041 | - | expression tag |
| Met 1042 | - | expression tag |
| Phe 1467 | Tyr 1467 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 1520 | - | linker |
| Gly 1521 | - | linker |
| Gly 1522 | - | linker |
| Ser 1523 | - | linker |
| Gly 1524 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 67102.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1489.1 | |
| All* | Total formula weight | 68591.8 |
