5LIK
Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK181
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Aldo-keto reductase family 1 member B10 | polymer | 316 | 36394.0 | 1 | UniProt (O60218) Pfam (PF00248) | Homo sapiens (Human) | ARL-1,Aldose reductase-like,Aldose reductase-related protein,hARP,Small intestine reductase,SI reductase |
| 2 | B (X) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 3 | C (X) | {2-[(4-bromobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid | non-polymer | 398.6 | 1 | Chemie (W8X) PubChem (18468153) | |||
| 4 | D (X) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (X) | water | water | 18.0 | 93 | Chemie (HOH) |
Sequence modifications
X: 1 - 316 (UniProt: O60218)
| PDB | External Database | Details |
|---|---|---|
| Arg 125 | Lys 125 | engineered mutation |
| Leu 301 | Val 301 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36394.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1204.1 | |
| All* | Total formula weight | 37598.1 |
