5LGJ

THE CRYSTAL STRUCTURE OF IGE FC MUTANT - P333C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ig epsilon chain C region	polymer	319	35531.9	1	UniProt (P01854) Pfam (PF07654)	Homo sapiens (Human)
2	B (B)	Ig epsilon chain C region	polymer	320	35588.9	1	UniProt (P01854) Pfam (PF07654)	Homo sapiens (Human)
3	C (C)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G10756ZZ)
4	D (D)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-4)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	1	In PDB GlyTouCan (G76464YC)
5	E, F, G, K (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
6	H, I (A)	TETRAETHYLENE GLYCOL	non-polymer		194.2	2	Chemie (PG4)
7	J (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
8	L, M (A, B)	water	water		18.0	235	Chemie (HOH)

Sequence modifications

A: 228 - 545 (UniProt: P01854)

PDB	External Database	Details
Gln 265	Asn 146	conflict
Cys 333	Pro 214	engineered mutation
Gln 371	Asn 252	conflict

B: 228 - 546 (UniProt: P01854)

PDB	External Database	Details
Gln 265	Asn 146	conflict
Cys 333	Pro 214	engineered mutation
Gln 371	Asn 252	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71120.8
Branched	Number of molecules	2
	Total formula weight	2145.9
Non-Polymers*	Number of molecules	7
	Total formula weight	864.8
All*	Total formula weight	74131.5

*Water molecules are not included.