5LF6
Human 20S proteasome complex with Z-LLY-ketoaldehyde at 2.1 Angstrom
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, P (A, O) | Proteasome subunit alpha type-2 | polymer | 234 | 25927.5 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3 |
| 2 | B, Q (B, P) | Proteasome subunit alpha type-4 | polymer | 261 | 29525.8 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L |
| 3 | C, R (C, Q) | Proteasome subunit alpha type-7 | polymer | 248 | 27986.9 | 2 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7 |
| 4 | D, S (D, R) | Proteasome subunit alpha type-5 | polymer | 241 | 26436.0 | 2 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain |
| 5 | E, T (E, S) | Proteasome subunit alpha type-1 | polymer | 263 | 29595.6 | 2 | UniProt (P25786) Pfam (PF00227) Pfam (PF10584) | Homo sapiens (human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain |
| 6 | F, U (F, T) | Proteasome subunit alpha type-3 | polymer | 255 | 28469.3 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8 |
| 7 | G, V (G, U) | Proteasome subunit alpha type-6 | polymer | 246 | 27489.5 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | 27 kDa prosomal protein,PROS-27,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain,Proteasome subunit alpha-1,alpha-1 |
| 8 | H, W (H, V) | Proteasome subunit beta type-7 | polymer | 234 | 25322.0 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | Homo sapiens (human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z |
| 9 | I, X (I, W) | Proteasome subunit beta type-3 | polymer | 205 | 22972.9 | 2 | UniProt (P49720) Pfam (PF00227) | Homo sapiens (human) | Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain |
| 10 | J, Y (J, X) | Proteasome subunit beta type-2 | polymer | 201 | 22864.3 | 2 | UniProt (P49721) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I |
| 11 | K, Z (c, d) | Z-LLY-ketoaldehyde peptide | polymer | 4 | 576.1 | 2 | Homo sapiens | ||
| 12 | AA, L (K, Y) | Proteasome subunit beta type-5 | polymer | 204 | 22484.4 | 2 | UniProt (P28074) Pfam (PF00227) | Homo sapiens (human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X |
| 13 | BA, M (L, Z) | Proteasome subunit beta type-1 | polymer | 213 | 23579.0 | 2 | UniProt (P20618) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain |
| 14 | CA, N (M, a) | Proteasome subunit beta type-4 | polymer | 219 | 24414.7 | 2 | UniProt (P28070) Pfam (PF00227) | Homo sapiens (human) | 26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3 |
| 15 | DA, O (N, b) | Proteasome subunit beta type-6 | polymer | 205 | 21921.8 | 2 | UniProt (P28072) Pfam (PF00227) | Homo sapiens (human) | Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y |
| 16 | AB, AC, AD, BB, BC... (H, O, Y, P, I...) | CHLORIDE ION | non-polymer | 35.5 | 55 | Chemie (CL) | |||
| 17 | HB, KC, NC, OC, RA... (J, S, U, E, G...) | 1-ETHYL-PYRROLIDINE-2,5-DIONE | non-polymer | 127.1 | 8 | Chemie (NEN) | Homo sapiens (human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain | |
| 18 | ED, MC, NB, ND, VA... (Z, U, L, b, G...) | POTASSIUM ION | non-polymer | 39.1 | 6 | Chemie (K) | |||
| 19 | CB, GB, IB, PC, QC... (I, J, K, V, W...) | MAGNESIUM ION | non-polymer | 24.3 | 10 | Chemie (MG) | |||
| 20 | DD, EB, FB, ID, MB... (Z, I, a, L, b...) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 9 | Chemie (1PE) | |||
| 21 | AE, BE, CE, DE, EE... (L, M, N, O, P...) | water | water | 18.0 | 3501 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 30 |
| Total formula weight | 719131.8 | |
| Non-Polymers* | Number of molecules | 88 |
| Total formula weight | 5589.2 | |
| All* | Total formula weight | 724721.0 |
