5LDE

Crystal structure of a vFLIP-IKKgamma stapled peptide dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Immunoglobulin G-binding protein G,Viral FLICE protein	polymer	265	30194.5	2	UniProt (P19909) UniProt (F5HEZ4) Pfam (PF01378) Pfam (PF01335) In PDB	Streptococcus sp. group G	IgG-binding protein G,vFLIP
2	R, S	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_a	polymer	20	2367.7	2	UniProt (D3DWY2) UniProt (by SIFTS) (Q9Y6K9) In PDB	Homo sapiens

Sequence modifications

A, B: 3 - 55 (UniProt: P19909)

PDB	External Database	Details
Met 1	-	initiating methionine
Gln 2	-	expression tag
Glu 56	-	linker
Leu 57	-	linker
Glu 58	-	linker
Val 59	-	linker
Leu 60	-	linker
Phe 61	-	linker
Gln 62	-	linker
Gly 63	-	linker
Pro 64	-	linker
Leu 65	-	linker
Asp 66	-	linker
Pro 67	-	linker
Asn 68	-	linker
Ser 69	-	linker

A, B: 101 - 288 (UniProt: F5HEZ4)

PDB	External Database	Details
Leu 289	-	expression tag
Glu 290	-	expression tag
His 291	-	expression tag
His 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag

R, S: 230 - 249 (UniProt: D3DWY2)

PDB	External Database	Details
6zs 236	Gln 51	engineered mutation
6zs 240	Glu 55	engineered mutation
Cys 249	Val 64	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	65124.4
All*	Total formula weight	65124.4

*Water molecules are not included.