5LBY

Structure of the human quinone reductase 2 (NQO2) in complex with crenolanib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Ribosyldihydronicotinamide dehydrogenase [quinone]	polymer	237	26775.4	2	UniProt (P16083) Pfam (PF02525) In PDB	Homo sapiens (Human)	NRH dehydrogenase [quinone] 2,NRH:quinone oxidoreductase 2,Quinone reductase 2,QR2
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A, B	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
4	A, B	1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine	non-polymer		443.5	2	Chemie (6T2)
5		water	water		18.0	436	Chemie (HOH)

Sequence modifications

A, B: 0 - 230 (UniProt: P16083)

PDB	External Database	Details
His 231	-	expression tag
His 232	-	expression tag
His 233	-	expression tag
His 234	-	expression tag
His 235	-	expression tag
His 236	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	53550.8
Non-Polymers*	Number of molecules	6
	Total formula weight	2589.0
All*	Total formula weight	56139.8

*Water molecules are not included.