5LBA
Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (B, A, C, D) | ATP-dependent DNA helicase Q5 | polymer | 445 | 49537.2 | 4 | UniProt (O94762) Pfam (PF00270) Pfam (PF00271) Pfam (PF16124) | Homo sapiens (Human) | DNA helicase,RecQ-like type 5,RecQ5,RecQ protein-like 5 |
| 2 | E, J, N, Q (B, A, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 3 | F, L, O, R (B, A, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G, K, P, S (B, A, C, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 5 | H, M, T (B, A, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 6 | I (B) | 1-cyclohexyl-3-[[(2~{R})-oxolan-2-yl]methyl]urea | non-polymer | 226.3 | 1 | Chemie (6SV) | |||
| 7 | U, V, W, X (B, A, C, D) | water | water | 18.0 | 338 | Chemie (HOH) |
Sequence modifications
B, A, C, D: 11 - 453 (UniProt: O94762)
| PDB | External Database | Details |
|---|---|---|
| Ser 9 | - | expression tag |
| Met 10 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 198148.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2528.4 | |
| All* | Total formula weight | 200677.1 |
