5LAY
Discovery of New Natural-product-inspired Spiro-oxindole Compounds as Orally Active Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6g
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | E3 ubiquitin-protein ligase Mdm2 | polymer | 95 | 11099.0 | 6 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | A, C, E | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 3 | A, B, D, E | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | A, B, C, D, E... | (3~{S},3'~{S},4'~{S},5'~{S})-4'-azanyl-6-chloranyl-3'-(3-chloranyl-2-fluoranyl-phenyl)-1'-[(3-ethoxyphenyl)methyl]-5'-methyl-spiro[1~{H}-indole-3,2'-pyrrolidine]-2-one | non-polymer | 514.4 | 6 | Chemie (6SS) | |||
| 5 | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 66594.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3931.2 | |
| All* | Total formula weight | 70525.2 |
