5L8K
Aurora-A kinase domain in complex with vNAR-D01 (crystal form 2)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aurora kinase A | polymer | 285 | 32964.6 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
2 | B | New antigen receptor variable domain | polymer | 117 | 12766.2 | 1 | UniProt (Q8JJ25) Pfam (PF07686) In PDB | Orectolobus maculatus (spotted wobbegong) | |
3 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
4 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
6 | water | water | 18.0 | 280 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
B: 2 - 104 (UniProt: Q8JJ25)
PDB | External Database | Details |
---|---|---|
Gly 119 | - | expression tag |
Ala 120 | - | expression tag |
Met 121 | - | expression tag |
Ala 290 | Cys 290 | engineered mutation |
Ala 393 | Cys 393 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Ile 87 | Tyr 86 | conflict |
Asp 88 | Arg 87 | conflict |
Ser 89 | Arg 88 | engineered mutation |
- | Ala 90 | deletion |
- | Phe 91 | deletion |
- | Asn 92 | deletion |
- | Thr 93 | deletion |
- | Gly 94 | deletion |
Trp 91 | Val 95 | conflict |
Leu 92 | Gly 96 | conflict |
Ser 93 | Tyr 97 | conflict |
Arg 94 | Lys 98 | conflict |
Gly 105 | - | expression tag |
Gly 106 | - | expression tag |
Ala 107 | - | expression tag |
Ala 108 | - | expression tag |
Ala 109 | - | expression tag |
Leu 110 | - | expression tag |
Glu 111 | - | expression tag |
His 112 | - | expression tag |
His 113 | - | expression tag |
His 114 | - | expression tag |
His 115 | - | expression tag |
His 116 | - | expression tag |
His 117 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 45730.8 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1240.0 | |
All* | Total formula weight | 46970.8 |