5L7D
Structure of human Smoothened in complex with cholesterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Smoothened homolog,Soluble cytochrome b562,Smoothened homolog | polymer | 638 | 70784.0 | 2 | UniProt (Q99835) UniProt (P0ABE7) Pfam (PF01392) Pfam (PF01534) | Homo sapiens (Human) | SMO,Protein Gx,Cytochrome b-562,SMO,Protein Gx |
| 2 | C, D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | E (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (176980071) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (44654663) PubChem (46937002) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (59274407) PubChem (45044259) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (1551269) PubChem (90070115) PubChem (49853509) PubChem (50990013) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (52934537) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (56621683) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (138967089) PubChem (139566851) PubChem (15939944) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (171828367) PubChem (173516975) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (101624109) PubChem (304) PubChem (124225449) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (124429284) PubChem (638019) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (1549081) PubChem (1553803) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (6419195) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (130459183) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 4 | F, G (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) |
Sequence modifications
A, B: 32 - 428 (UniProt: Q99835)
A, B: 1016 - 1120 (UniProt: P0ABE7)
A, B: 1129 - 555 (UniProt: Q99835)
| PDB | External Database | Details |
|---|---|---|
| Phe 329 | Val 329 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Trp 1022 | Met 29 | conflict |
| Ile 1117 | His 124 | conflict |
| Leu 1121 | - | linker |
| Glu 1122 | - | linker |
| Arg 1123 | - | linker |
| Ala 1124 | - | linker |
| Arg 1125 | - | linker |
| Ser 1126 | - | linker |
| Thr 1127 | - | linker |
| Leu 1128 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 1011 | - | linker |
| Arg 1012 | - | linker |
| Arg 1013 | - | linker |
| Gln 1014 | - | linker |
| Leu 1015 | - | linker |
| Gly 556 | - | expression tag |
| Thr 557 | - | expression tag |
| Glu 558 | - | expression tag |
| Thr 559 | - | expression tag |
| Ser 560 | - | expression tag |
| Gln 561 | - | expression tag |
| Val 562 | - | expression tag |
| Ala 563 | - | expression tag |
| Pro 564 | - | expression tag |
| Ala 565 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 141567.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 875.0 | |
| All* | Total formula weight | 142443.0 |
