5L78

Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in NAD+ bound form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Alpha-aminoadipic semialdehyde synthase, mitochondrial	polymer	497	54622.8	2	UniProt (Q9UDR5) Pfam (PF03435) Pfam (PF16653)	Homo sapiens (Human)	LKR/SDH
2	C, D, E (A)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
3	F, G (A, B)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	2	Chemie (NAD)
4	H, I (A, B)	water	water		18.0	110	Chemie (HOH)

Sequence modifications

A, B: 455 - 926 (UniProt: Q9UDR5)

PDB	External Database	Details
Met 430	-	initiating methionine
Gly 431	-	expression tag
His 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
Ser 438	-	expression tag
Ser 439	-	expression tag
Gly 440	-	expression tag
Val 441	-	expression tag
Asp 442	-	expression tag
Leu 443	-	expression tag
Gly 444	-	expression tag
Thr 445	-	expression tag
Glu 446	-	expression tag
Asn 447	-	expression tag
Leu 448	-	expression tag
Tyr 449	-	expression tag
Phe 450	-	expression tag
Gln 451	-	expression tag
Ser 452	-	expression tag
Met 453	-	expression tag
Ala 454	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	109245.7
Non-Polymers*	Number of molecules	5
	Total formula weight	1513.1
All*	Total formula weight	110758.7

*Water molecules are not included.