5L5Z
Yeast 20S proteasome with human beta5c (1-138) and human beta6 (97-111; 118-133) in complex with bortezomib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, O | Proteasome subunit alpha type-2 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit Y7,Multicatalytic endopeptidase complex subunit Y7,Proteasome component Y7,Proteinase YSCE subunit 7 |
2 | B, P | Proteasome subunit alpha type-3 | polymer | 258 | 28748.2 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit Y13,Multicatalytic endopeptidase complex subunit Y13,Proteasome component Y13,Proteinase YSCE subunit 13 |
3 | C, Q | Proteasome subunit alpha type-4 | polymer | 254 | 28478.1 | 2 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PRE6,Multicatalytic endopeptidase complex subunit PRE6,Proteasome component PRE6,Proteinase YSCE subunit PRE6 |
4 | D, R | Proteasome subunit alpha type-5 | polymer | 260 | 28649.1 | 2 | UniProt (P32379) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PUP2,Multicatalytic endopeptidase complex subunit PUP2,Proteasome component PUP2,Proteinase YSCE subunit PUP2 |
5 | E, S | Proteasome subunit alpha type-6 | polymer | 234 | 25634.0 | 2 | UniProt (P40302) Pfam (PF00227) Pfam (PF10584) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PRE5,Multicatalytic endopeptidase complex subunit PRE5,Proteasome component PRE5,Proteinase YSCE subunit PRE5 |
6 | F, T | Probable proteasome subunit alpha type-7 | polymer | 288 | 31575.1 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit C1,Multicatalytic endopeptidase complex subunit C1,Proteasome component C1,Proteinase YSCE subunit 1 |
7 | G, U | Proteasome subunit alpha type-1 | polymer | 252 | 28033.8 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit C7-alpha,Multicatalytic endopeptidase complex C7,Proteasome component C7-alpha,Proteasome component Y8,Proteinase YSCE subunit 7,SCL1 suppressor protein |
8 | H, V | Proteasome subunit beta type-2 | polymer | 232 | 25114.5 | 2 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PUP1,Multicatalytic endopeptidase complex subunit PUP1,Proteasome component PUP1,Proteinase YSCE subunit PUP1 |
9 | I, W | Proteasome subunit beta type-3 | polymer | 205 | 22627.8 | 2 | UniProt (P25451) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PUP3,Multicatalytic endopeptidase complex subunit PUP3,Proteasome component PUP3 |
10 | J, X | Proteasome subunit beta type-4 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit C11,Multicatalytic endopeptidase complex subunit C11,Proteasome component C11,Proteinase YSCE subunit 11 |
11 | K, Y | Proteasome subunit beta type-5,Proteasome subunit beta type-5 | polymer | 211 | 23177.2 | 2 | UniProt (P28074) UniProt (P30656) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X,Macropain subunit PRE2,Multicatalytic endopeptidase complex subunit PRE2,Proteasome component PRE2,Proteinase YSCE subunit PRE2 |
12 | L, Z | Proteasome subunit beta type-6,Proteasome subunit beta type-1,Proteasome subunit beta type-6,Proteasome subunit beta type-1,Proteasome subunit beta type-6 | polymer | 222 | 24979.0 | 2 | UniProt (P23724) UniProt (P20618) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5 |
13 | M, a | Proteasome subunit beta type-7 | polymer | 246 | 27200.9 | 2 | UniProt (P30657) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PRE4,Multicatalytic endopeptidase complex subunit PRE4,Proteasome component PRE4,Proteinase YSCE subunit PRE4 |
14 | N, b | Proteasome subunit beta type-1 | polymer | 196 | 21517.2 | 2 | UniProt (P38624) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Macropain subunit PRE3,Multicatalytic endopeptidase complex subunit PRE3,Proteasome component PRE3,Proteinase YSCE subunit PRE3 |
15 | G, I, J, K, L... | MAGNESIUM ION | non-polymer | 24.3 | 10 | Chemie (MG) | |||
16 | G, N, U, b | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
17 | H, K, N, V, Y... | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | non-polymer | 384.2 | 6 | Chemie (BO2) | |||
18 | water | water | 18.0 | 480 | Chemie (HOH) |
Sequence modifications
K, Y: 1 - 138 (UniProt: P28074)
K, Y: 139 - 211 (UniProt: P30656)
L, Z: 1 - 96 (UniProt: P23724)
L, Z: 97 - 111 (UniProt: P20618)
L, Z: 112 - 117 (UniProt: P23724)
L, Z: 118 - 133 (UniProt: P20618)
L, Z: 134 - 222 (UniProt: P23724)
K, Y: 139 - 211 (UniProt: P30656)
L, Z: 1 - 96 (UniProt: P23724)
L, Z: 97 - 111 (UniProt: P20618)
L, Z: 112 - 117 (UniProt: P23724)
L, Z: 118 - 133 (UniProt: P20618)
L, Z: 134 - 222 (UniProt: P23724)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 28 |
Total formula weight | 730944.9 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 2690.3 | |
All* | Total formula weight | 733635.1 |