5L4N
Leishmania major Pteridine reductase 1 (PTR1) in complex with compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Pteridine reductase 1 | polymer | 288 | 30456.6 | 4 | UniProt (Q01782) Pfam (PF13561) In PDB | Leishmania major | H region methotrexate resistance protein |
| 2 | A, B | (2~{R})-2-(3-hydroxyphenyl)-6-oxidanyl-2,3-dihydrochromen-4-one | non-polymer | 256.3 | 2 | Chemie (6QT) | |||
| 3 | A, B, C, D | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | B | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | D | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 8 | D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 9 | water | water | 18.0 | 563 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 288 (UniProt: Q01782)
| PDB | External Database | Details |
|---|---|---|
| Val 162 | Phe 162 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 121826.3 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 4087.8 | |
| All* | Total formula weight | 125914.1 |
