5L2K
Crystal structure of GEM42 TCR-CD1b-GMM complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | T-cell surface glycoprotein CD1b | polymer | 300 | 33488.6 | 1 | UniProt (P29016) Pfam (PF16497) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B (B) | Beta-2-microglobulin | polymer | 98 | 11617.0 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (D) | GEM42 TCR alpha chain | polymer | 204 | 22646.1 | 1 | Homo sapiens | ||
| 4 | D (E) | GEM42 TCR beta chain | polymer | 243 | 27312.6 | 1 | Homo sapiens | ||
| 5 | E, F, G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | H, I, J, Q, S (A, D, E) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 7 | K, L, M, P (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 8 | N, T (A, E) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 9 | O (A) | TETRACOSYL PALMITATE | non-polymer | 593.1 | 1 | Chemie (6UL) | |||
| 10 | R (D) | CESIUM ION | non-polymer | 132.9 | 1 | Chemie (CS) | |||
| 11 | U (E) | 6-O-[(2R,3R)-3-hydroxy-2-tetradecyldocosanoyl]-alpha-L-idopyranose | non-polymer | 715.1 | 1 | Chemie (70E) | |||
| 12 | V, W, X (A, B, D) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 2 - 278 (UniProt: P29016)
| PDB | External Database | Details |
|---|---|---|
| Ala 160 | Ile 178 | engineered mutation |
| Gly 279 | - | expression tag |
| Ser 280 | - | expression tag |
| Gly 281 | - | expression tag |
| Leu 282 | - | expression tag |
| Asn 283 | - | expression tag |
| Asp 284 | - | expression tag |
| Ile 285 | - | expression tag |
| Phe 286 | - | expression tag |
| Glu 287 | - | expression tag |
| Ala 288 | - | expression tag |
| Gln 289 | - | expression tag |
| Lys 290 | - | expression tag |
| Ile 291 | - | expression tag |
| Glu 292 | - | expression tag |
| Trp 293 | - | expression tag |
| His 294 | - | expression tag |
| Glu 295 | - | expression tag |
| His 296 | - | expression tag |
| His 297 | - | expression tag |
| His 298 | - | expression tag |
| His 299 | - | expression tag |
| His 300 | - | expression tag |
| His 301 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 95064.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2772.8 | |
| All* | Total formula weight | 97837.0 |
