5KZ0

Structure of Human Anaplastic Lymphoma Kinase in Complex With 2-[(1R)-1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]-4-fluoro-N,N-dimethylbenzamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ALK tyrosine kinase receptor	polymer	327	36909.4	1	UniProt (Q9UM73) Pfam (PF07714) In PDB	Homo sapiens (Human)	Anaplastic lymphoma kinase
2	A	2-[(1~{R})-1-[2-azanyl-5-(1,3-dimethylpyrazol-4-yl)pyridin-3-yl]oxyethyl]-4-fluoranyl-~{N},~{N}-dimethyl-benzamide	non-polymer		397.4	1	Chemie (6YL)
3		water	water		18.0	196	Chemie (HOH)

Sequence modifications

A: 1093 - 1411 (UniProt: Q9UM73)

PDB	External Database	Details
Met 1085	-	initiating methionine
Ala 1086	-	expression tag
His 1087	-	expression tag
His 1088	-	expression tag
His 1089	-	expression tag
His 1090	-	expression tag
His 1091	-	expression tag
His 1092	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36909.4
Non-Polymers*	Number of molecules	1
	Total formula weight	397.4
All*	Total formula weight	37306.8

*Water molecules are not included.