5KYE
Crystal structure of USP7 catalytic domain [H294E] mutant in complex with ubiquitin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Ubiquitin carboxyl-terminal hydrolase 7 | polymer | 351 | 40578.8 | 2 | UniProt (Q93009) Pfam (PF00443) | Homo sapiens (Human) | Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7 |
| 2 | B, D (D, C) | Polyubiquitin-B | polymer | 76 | 8576.8 | 2 | UniProt (P0CG47) Pfam (PF00240) | Homo sapiens (Human) | |
| 3 | E (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | F, G, H, I (A, D, B, C) | water | water | 18.0 | 390 | Chemie (HOH) |
Sequence modifications
A, B: 208 - 554 (UniProt: Q93009)
| PDB | External Database | Details |
|---|---|---|
| Gly 204 | - | expression tag |
| Ser 205 | - | expression tag |
| His 206 | - | expression tag |
| Met 207 | - | expression tag |
| Glu 294 | His 278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 98311.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 238.3 | |
| All* | Total formula weight | 98549.7 |
