5KWG
Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Receptor tyrosine-protein kinase erbB-2 | polymer | 631 | 69507.9 | 1 | UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (Human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
| 2 | B (A) | Ig gamma-1 chain C region | polymer | 228 | 25770.2 | 1 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (Human) |
Sequence modifications
A: 225 - 447 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Tyr 358 | Leu 241 | engineered mutation |
| Leu 359 | Thr 242 | engineered mutation |
| Tyr 360 | Lys 243 | engineered mutation |
| Gly 361 | Asn 244 | engineered mutation |
| Asp 362 | Gln 245 | engineered mutation |
| Pro 413 | Asp 296 | engineered mutation |
| Arg 414 | Lys 297 | engineered mutation |
| His 415 | Ser 298 | engineered mutation |
| Ser 415 | - | insertion |
| Ala 415 | - | insertion |
| Arg 415 | - | insertion |
| Met 415 | - | insertion |
| Trp 415 | - | insertion |
| Ala 418 | Gln 301 | engineered mutation |
| His 419 | Gln 302 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 95278.1 | |
| All* | Total formula weight | 95278.1 |
