5KOQ
Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Renin | polymer | 337 | 36939.6 | 2 | UniProt (P00797) Pfam (PF00026) In PDB | Homo sapiens (Human) | Angiotensinogenase |
| 2 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | A, B | 2-~{tert}-butyl-4-(furan-2-ylmethylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S})-piperidin-3-yl]pyrimidine-5-carboxamide | non-polymer | 413.6 | 2 | Chemie (6VR) | |||
| 4 | B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73879.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1375.6 | |
| All* | Total formula weight | 75254.8 |
