5KNM

Human leukocyte antigen F (HLA-F) presents peptides and regulates immunity through interactions with NK-cell receptors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	cDNA FLJ39643 fis, clone SMINT2004023, highly similar to HLA class I histocompatibility antigen, alphachain F	polymer	284	32769.1	1	UniProt (B3KUD8) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P30511)	Homo sapiens (Human)
2	B (B)	Beta-2-microglobulin	polymer	182	20060.3	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C (D)	Leukocyte immunoglobulin-like receptor subfamily B member 1	polymer	267	29467.0	1	UniProt (Q8NHL6) Pfam (PF13895)	Homo sapiens (Human)	Leukocyte immunoglobulin-like receptor 1,CD85 antigen-like family member J,Immunoglobulin-like transcript 2,ILT-2,Monocyte/macrophage immunoglobulin-like receptor 7,MIR-7
4	D (N)	Peptide ILE-LEU-ARG-TRP-GLU-GLN	polymer	6	845.0	1		Trichoplusia ni
5	E (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met -68	-	initiating methionine
Leu -67	-	expression tag
Leu -66	-	expression tag
Val -65	-	expression tag
Asn -64	-	expression tag
Gln -63	-	expression tag
Ser -62	-	expression tag
His -61	-	expression tag
Gln -60	-	expression tag
Gly -59	-	expression tag
Phe -58	-	expression tag
Asn -57	-	expression tag
Lys -56	-	expression tag
Glu -55	-	expression tag
His -54	-	expression tag
Thr -53	-	expression tag
Ser -52	-	expression tag
Lys -51	-	expression tag
Met -50	-	expression tag
Val -49	-	expression tag
Ser -48	-	expression tag
Ala -47	-	expression tag
Ile -46	-	expression tag
Val -45	-	expression tag
Leu -44	-	expression tag
Tyr -43	-	expression tag
Val -42	-	expression tag
Leu -41	-	expression tag
Leu -40	-	expression tag
Ala -39	-	expression tag
Ala -38	-	expression tag
Ala -37	-	expression tag
Ala -36	-	expression tag
His -35	-	expression tag
Ser -34	-	expression tag
Ala -33	-	expression tag
Phe -32	-	expression tag
Ala -31	-	expression tag
Ala -30	-	expression tag
Asp -29	-	expression tag
Leu -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Gly -17	-	expression tag
Gly -16	-	expression tag
Leu -15	-	expression tag
Glu -14	-	expression tag
Val -13	-	expression tag
Leu -12	-	expression tag
Phe -11	-	expression tag
Gln -10	-	expression tag
Gly -9	-	expression tag
Pro -8	-	expression tag
Glu -7	-	expression tag
Phe -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Ala -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag
Gly 100	-	expression tag
Gly 101	-	expression tag
Gly 102	-	expression tag
Gly 103	-	expression tag
Ser 104	-	expression tag
Gly 105	-	expression tag
Gly 106	-	expression tag
Ser 107	-	expression tag
Gly 108	-	expression tag
Ser 109	-	expression tag
Gly 110	-	expression tag
Gly 111	-	expression tag
Gly 112	-	expression tag
Ser 113	-	expression tag

D: 1 - 198 (UniProt: Q8NHL6)

PDB	External Database	Details
Met -68	-	initiating methionine
Leu -67	-	expression tag
Leu -66	-	expression tag
Val -65	-	expression tag
Asn -64	-	expression tag
Gln -63	-	expression tag
Ser -62	-	expression tag
His -61	-	expression tag
Gln -60	-	expression tag
Gly -59	-	expression tag
Phe -58	-	expression tag
Asn -57	-	expression tag
Lys -56	-	expression tag
Glu -55	-	expression tag
His -54	-	expression tag
Thr -53	-	expression tag
Ser -52	-	expression tag
Lys -51	-	expression tag
Met -50	-	expression tag
Val -49	-	expression tag
Ser -48	-	expression tag
Ala -47	-	expression tag
Ile -46	-	expression tag
Val -45	-	expression tag
Leu -44	-	expression tag
Tyr -43	-	expression tag
Val -42	-	expression tag
Leu -41	-	expression tag
Leu -40	-	expression tag
Ala -39	-	expression tag
Ala -38	-	expression tag
Ala -37	-	expression tag
Ala -36	-	expression tag
His -35	-	expression tag
Ser -34	-	expression tag
Ala -33	-	expression tag
Phe -32	-	expression tag
Ala -31	-	expression tag
Ala -30	-	expression tag
Asp -29	-	expression tag
Leu -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Gly -17	-	expression tag
Gly -16	-	expression tag
Leu -15	-	expression tag
Glu -14	-	expression tag
Val -13	-	expression tag
Leu -12	-	expression tag
Phe -11	-	expression tag
Gln -10	-	expression tag
Gly -9	-	expression tag
Pro -8	-	expression tag
Glu -7	-	expression tag
Phe -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Ala -2	-	expression tag
Asp -1	-	expression tag
Leu 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	83141.4
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	83362.6

*Water molecules are not included.