5KMN

TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	High affinity nerve growth factor receptor	polymer	330	37292.8	1	UniProt (P04629) Pfam (PF07714) In PDB	Homo sapiens (Human)	Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA
2	A	1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea	non-polymer		386.4	1	Chemie (6UK)
3		water	water		18.0	88	Chemie (HOH)

Sequence modifications

A: 474 - 796 (UniProt: P04629)

PDB	External Database	Details
Ace 0	-	acetylation
His 797	-	expression tag
His 798	-	expression tag
His 799	-	expression tag
His 800	-	expression tag
His 801	-	expression tag
His 802	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37292.8
Non-Polymers*	Number of molecules	1
	Total formula weight	386.4
All*	Total formula weight	37679.2

*Water molecules are not included.