5KLY
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant adenosine nucleoside phosphoramidate substrate complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histidine triad nucleotide-binding protein 1 | polymer | 129 | 14072.1 | 2 | UniProt (P49773) Pfam (PF01230) | Homo sapiens (Human) | Adenosine 5'-monophosphoramidase |
| 2 | C (A) | [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]p hosphonamidic acid | non-polymer | 489.4 | 1 | Chemie (6UR) | |||
| 3 | D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | E (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 312 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 126 (UniProt: P49773)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Asn 112 | His 112 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28144.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 631.0 | |
| All* | Total formula weight | 28775.3 |
