5KKT
ROCK 1 bound to azaindole thiazole piperazine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Rho-associated protein kinase 1 | polymer | 415 | 48012.3 | 2 | UniProt (Q13464) Pfam (PF00069) | Homo sapiens (Human) | Renal carcinoma antigen NY-REN-35, Rho-associated,coiled-coil-containing protein kinase 1, coiled-coil-containing protein kinase I, ROCK-I, p160 ROCK-1, p160ROCK |
| 2 | C, D (A, B) | 2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{N}-[4-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide | non-polymer | 490.6 | 2 | Chemie (6U2) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 192 | Chemie (HOH) |
Sequence modifications
A, B: 6 - 415 (UniProt: Q13464)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Ser 2 | - | cloning artifact |
| Leu 3 | - | cloning artifact |
| His 4 | - | cloning artifact |
| Met 5 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96024.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 981.2 | |
| All* | Total formula weight | 97005.8 |
