5KDR

The crystal structure of carboxyltransferase from Staphylococcus Aureus bound to the antimicrobial agent moiramide B.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha	polymer	327	36684.7	1	UniProt (Q2FG38) Pfam (PF03255) UniProt (by SIFTS) (Q2FXM7)	Staphylococcus aureus (strain USA300)	Acetyl-CoA carboxylase carboxyltransferase subunit alpha
2	B (B)	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	polymer	285	31916.8	1	UniProt (Q2YTE0) Pfam (PF17848) Pfam (PF01039) UniProt (by SIFTS) (Q2FXM6)	Staphylococcus aureus (strain bovine RF122 / ET3-1)	Acetyl-CoA carboxylase carboxyltransferase subunit beta
3	C, D, F (A, B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	E (B)	Moiramide B	non-polymer		453.5	1	Chemie (YT5)
5	G (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	H (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
7	I, J (A, B)	water	water		18.0	21	Chemie (HOH)

Sequence modifications

A: 1 - 314 (UniProt: Q2FG38)

PDB	External Database	Details
Met -12	-	initiating methionine
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Leu -5	-	expression tag
Val -4	-	expression tag
Pro -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68601.5
Non-Polymers*	Number of molecules	6
	Total formula weight	869.2
All*	Total formula weight	69470.7

*Water molecules are not included.