5KCT
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with an N-ethyl, 4-chlorobenzyl OBHS-N derivative
Replaces: 5BNUEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 257 | 29299.5 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (C, D) | NCOA2 | polymer | 14 | 1666.9 | 2 | UniProt (by SIFTS) (Q15596) | Homo sapiens | |
| 3 | E (A) | (1R,2S,4R)-N-(4-chlorophenyl)-N-ethyl-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide | non-polymer | 498.0 | 1 | Chemie (OB7) | |||
| 4 | F (B) | (1S,2R,4S)-N-(4-chlorophenyl)-N-ethyl-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide | non-polymer | 498.0 | 1 | Chemie (OB6) | |||
| 5 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 361 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61933.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 996.0 | |
| All* | Total formula weight | 62928.9 |
