5KBV

Cryo-EM structure of GluA2 bound to antagonist ZK200775 at 6.8 Angstrom resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2	polymer	822	92252.3	4	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	A, B, C, D	{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid	non-polymer		409.3	4	Chemie (ZK1)
3	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, B, C, D: 10 - 826 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	engineered mutation
Leu 382	Val 397	engineered mutation
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	engineered mutation
Asp 385	Asn 406	engineered mutation
Gln 392	Asn 413	conflict
Leu 758	Val 779	engineered mutation
Gly 827	-	expression tag
Leu 828	-	expression tag
Val 829	-	expression tag
Pro 830	-	expression tag
Arg 831	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	369009.4
Non-Polymers*	Number of molecules	8
	Total formula weight	2521.8
All*	Total formula weight	371531.2

*Water molecules are not included.