5KBT
Cryo-EM structure of GluA2-1xSTZ complex at 6.4 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit | polymer | 1034 | 115516.0 | 4 | UniProt (P19491) UniProt (O88602) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822) | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2 |
| 2 | E, G, I, K (A, B, C, D) | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 4 | Chemie (ZK1) | |||
| 3 | F, H, J, L (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 10 - 826 (UniProt: P19491)
A, B, C, D: 1001 - 1207 (UniProt: O88602)
| PDB | External Database | Details |
|---|---|---|
| Glu 241 | Asn 256 | engineered mutation |
| Leu 382 | Val 397 | engineered mutation |
| - | Leu 399 | deletion |
| - | Thr 400 | deletion |
| - | Glu 401 | deletion |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| - | Ser 404 | deletion |
| Glu 384 | Gly 405 | engineered mutation |
| Asp 385 | Asn 406 | engineered mutation |
| Gln 392 | Asn 413 | conflict |
| Leu 758 | Val 779 | engineered mutation |
| Gly 827 | - | linker |
| Thr 828 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asp 1047 | Asn 48 | conflict |
| Thr 1208 | - | expression tag |
| Gly 1209 | - | expression tag |
| Gly 1210 | - | expression tag |
| Leu 1211 | - | expression tag |
| Val 1212 | - | expression tag |
| Pro 1213 | - | expression tag |
| Arg 1214 | - | expression tag |
| Gly 1215 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 462063.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2521.8 | |
| All* | Total formula weight | 464585.8 |
