5KBT

Cryo-EM structure of GluA2-1xSTZ complex at 6.4 Angstrom resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit	polymer	1034	115516.0	4	UniProt (P19491) UniProt (O88602) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822)	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2
2	E, G, I, K (A, B, C, D)	{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid	non-polymer		409.3	4	Chemie (ZK1)
3	F, H, J, L (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, B, C, D: 10 - 826 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	engineered mutation
Leu 382	Val 397	engineered mutation
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	engineered mutation
Asp 385	Asn 406	engineered mutation
Gln 392	Asn 413	conflict
Leu 758	Val 779	engineered mutation
Gly 827	-	linker
Thr 828	-	linker

A, B, C, D: 1001 - 1207 (UniProt: O88602)

PDB	External Database	Details
Asp 1047	Asn 48	conflict
Thr 1208	-	expression tag
Gly 1209	-	expression tag
Gly 1210	-	expression tag
Leu 1211	-	expression tag
Val 1212	-	expression tag
Pro 1213	-	expression tag
Arg 1214	-	expression tag
Gly 1215	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	462063.9
Non-Polymers*	Number of molecules	8
	Total formula weight	2521.8
All*	Total formula weight	464585.8

*Water molecules are not included.