5KBR
Pak1 in complex with 7-azaindole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein kinase PAK 1 | polymer | 289 | 32332.3 | 2 | UniProt (Q13153) Pfam (PF00069) In PDB | Homo sapiens (Human) | Alpha-PAK,p21-activated kinase 1,PAK-1,p65-PAK |
| 2 | A, B | (4-chlorophenyl)-[5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]methanone | non-polymer | 405.9 | 2 | Chemie (IPW) | |||
| 3 | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A, B: 254 - 542 (UniProt: Q13153)
| PDB | External Database | Details |
|---|---|---|
| Asn 389 | Asp 389 | engineered mutation |
| Glu 423 | Thr 423 | engineered mutation |
| Asp 503 | Glu 503 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64664.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 811.8 | |
| All* | Total formula weight | 65476.5 |
