5K5T

Crystal structure of the inactive form of human calcium-sensing receptor extracellular domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Extracellular calcium-sensing receptor	polymer	615	69227.6	1	UniProt (P41180) Pfam (PF01094) Pfam (PF07562)	Homo sapiens (Human)	CaSR,Parathyroid cell calcium-sensing receptor 1,PCaR1
2	B (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
3	C, D, E (A)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	F, G, H, I, J... (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)
5	M (A)	water	water		18.0	43	Chemie (HOH)

Sequence modifications

A: 20 - 607 (UniProt: P41180)

PDB	External Database	Details
Met 1	-	initiating methionine
Ala 2	-	expression tag
Phe 3	-	expression tag
Tyr 4	-	expression tag
Ser 5	-	expression tag
Cys 6	-	expression tag
Cys 7	-	expression tag
Trp 8	-	expression tag
Val 9	-	expression tag
Leu 10	-	expression tag
Leu 11	-	expression tag
Ala 12	-	expression tag
Leu 13	-	expression tag
Thr 14	-	expression tag
Trp 15	-	expression tag
His 16	-	expression tag
Thr 17	-	expression tag
Ser 18	-	expression tag
Ala 19	-	expression tag
Gln 386	Asn 386	engineered mutation
Asn 402	Ser 402	engineered mutation
Asp 608	-	expression tag
Tyr 609	-	expression tag
Lys 610	-	expression tag
Asp 611	-	expression tag
Asp 612	-	expression tag
Asp 613	-	expression tag
Asp 614	-	expression tag
Lys 615	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	69227.6
Non-Polymers*	Number of molecules	11
	Total formula weight	1876.7
All*	Total formula weight	71104.3

*Water molecules are not included.