5K22

Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Protein tyrosine phosphatase type IVA 2	polymer	183	20796.9	1	UniProt (Q12974) Pfam (PF00102) In PDB	Homo sapiens (Human)	HU-PP-1,OV-1,PTP(CAAXII),Protein-tyrosine phosphatase 4a2,Protein-tyrosine phosphatase of regenerating liver 2,PRL-2
2	B	Metal transporter CNNM3	polymer	155	17634.0	1	UniProt (Q8NE01) Pfam (PF00571) In PDB	Homo sapiens (Human)	Ancient conserved domain-containing protein 3,Cyclin-M3
3		water	water		18.0	6	Chemie (HOH)

Sequence modifications

A: 1 - 163 (UniProt: Q12974)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Ala 95	Cys 95	engineered mutation
Ala 96	Cys 96	engineered mutation
Ala 119	Cys 119	engineered mutation

B: 309 - 452 (UniProt: Q8NE01)

PDB	External Database	Details
Gly 298	-	expression tag
Pro 299	-	expression tag
Leu 300	-	expression tag
Asn 301	-	expression tag
Met 302	-	expression tag
Ile 303	-	expression tag
Gln 304	-	expression tag
Gly 305	-	expression tag
Val 306	-	expression tag
Leu 307	-	expression tag
Glu 308	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38430.9
All*	Total formula weight	38430.9

*Water molecules are not included.