5K1I
PDE4 crystal structure in complex with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 326 | 37578.6 | 8 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | AA, DA, I, L, O... (G, H, A, B, C...) | 4-[(5-acetyl-2-ethyl-3-oxo-6-phenyl-2,3-dihydropyridazin-4-yl)amino]benzoic acid | non-polymer | 377.4 | 8 | Chemie (6PT) | |||
| 3 | BA, EA, J, M, P... (G, H, A, B, C...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 4 | CA, FA, K, N, Q... (G, H, A, B, C...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 5 | GA, HA, IA, JA, KA... (A, B, C, D, E...) | water | water | 18.0 | 210 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 300628.8 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 3736.9 | |
| All* | Total formula weight | 304365.6 |
