5K11
Cryo-EM structure of isocitrate dehydrogenase (IDH1) in inhibitor-bound state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Isocitrate dehydrogenase [NADP] cytoplasmic | polymer | 411 | 46334.7 | 2 | UniProt (O75874) Pfam (PF00180) In PDB | Homo sapiens (Human) | IDH, Cytosolic NADP-isocitrate dehydrogenase, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase |
| 2 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) |
Sequence modifications
A, B: 3 - 413 (UniProt: O75874)
| PDB | External Database | Details |
|---|---|---|
| Cys 132 | Arg 132 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92669.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1490.8 | |
| All* | Total formula weight | 94160.3 |
