5JZN
Crystal structure of DCLK1-KD in complex with NVP-TAE684
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase DCLK1 | polymer | 280 | 31299.7 | 2 | UniProt (O15075) Pfam (PF00069) | Homo sapiens (Human) | Doublecortin domain-containing protein 3A,Doublecortin-like and CAM kinase-like 1,Doublecortin-like kinase 1 |
| 2 | C, E (A, B) | 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE | non-polymer | 614.2 | 2 | Chemie (GUI) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, B: 372 - 649 (UniProt: O15075)
| PDB | External Database | Details |
|---|---|---|
| Gly 370 | - | expression tag |
| Ser 371 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62599.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1324.5 | |
| All* | Total formula weight | 63924.0 |
